N-methylated ERAP1substrate
Ref. 3D-CRB1000327
1mg
265.00€
500µg
194.00€
Product Information
Name:N-methylated ERAP1substrate
Synonyms:
- H-L(NMeV)AFKARAF-OH
Brand:Biosynth
Description:Non-hydrolysable ERAP1 substrate. An optimized ERAP1 substrate with N-methylation of the first amide bond to prevent its degradation by ERAP1.Endoplasmic reticulum aminopeptidase 1 and 2 (ERAP1 and ERAP2) are ER-resident, interferon-γ inducible, metalloaminopeptidase which critically shape the major histocompatibility complex I (MHC I) immunopeptidome. The ERAPs remove N-terminal residues from antigenic precursor peptides and generate optimal-length peptides (i.e. 8-10-mers) to fit into the MHC class I groove. The immune recognition of surface MHC I/peptide complexes initiates activation of CD8+ T cells as a critical step in the elimination of pathogens.ERAP1 has unique substrate preferences, trimming long peptides while sparing shorter ones as well as sequence preferences. ERAP1 and ERAP2 can form a heterodimer (ERAP1/ERAP2) with distinct functional properties. Allelic variants of ERAP1 have been linked to a number of human diseases, including the autoimmune disease ankylosing spondylitis (AS), diabetes, some forms of cervical cancer, and hypertension.
Notice:Our products are intended for lab use only. For any other use, please contact us.
Chemical properties
Molecular weight:1,035.6 g/mol
Color/Form:Powder
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