Cilengitide (Linear)
Ref. 3D-CRB1001070
1mg
265.00€
500µg
194.00€
Product Information
Name:Cilengitide (Linear)
Synonyms:
- H-RGDFV-OH
Brand:Biosynth
Description:Cilengitide is a cyclic arginine-glycine-aspartic acid (RGD) motif containing peptide that selectively inhibits the integrin alphav subunit. Integrins are cell adhesion molecules which mediate cell-cell and cell-matrix interactions and creating a scaffold for tissue organisation. Integrins also act to regulate cell attachment, proliferation, differentiation, apoptosis and motility.Integrin alphav can form heterodimers with integrin subunits subunits β1, β3, β5, β6, or β8. Cilengitide is a highly specific antagonist of alphavβ3 and alphavβ5 integrins. It also and shows anti-angiogenic effects and inhibits growth and promotes apoptosis of tumour cells that express integrins, such as glioblastoma.Cilengitide has gone on to phase II trials for cancers such as glioblastoma, melanoma, prostate, breast, lung and head and neck cancers.
Notice:Our products are intended for lab use only. For any other use, please contact us.
Chemical properties
Molecular weight:592.3 g/mol
Technical inquiry about: Cilengitide (Linear)
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