alpha-gliadin (58-73)
Ref. 3D-CRB1001204
1mg
265.00€
500µg
194.00€
Product Information
Name:alpha-gliadin (58-73)
Synonyms:
- H-KLQPFPQPELPYPQPQ-OHKLQPFPQPELPYPQPQ-acidH-Lys-Leu-Gln-Pro-Phe-Pro-Gln-Pro-Glu-Leu-Pro-Tyr-Pro-Gln-Pro-Gln-OHAlpha-gliadin (58-7 3)
Brand:Biosynth
Description:α-Gliadin (58-73) is derived from Gliadin peptides, the component of wheat involved in the gastrointestinal symptoms of wheat allergy and Celiac Disease (CD). During wheat allergies histamines and leukotrienes are secreted due to gliadin peptide sequences cross-linking two IgE molecules on mast cells and basophils.The glutamine and proline rich peptides of which Gliadin is composed of are resistant to proteolysis during digestion, leaving them active in the gastrointestinal tract. Subsequently these are deamidated by tissue transglutaminase and can bind to HLA-DQ2 or DQ8. As a result in patients with the autoimmune disease CD, there is a Th1-mediated inflammatory immune response against these gliadin peptides.Gliadin can exert additional effects on the intestinal microbiota and ileal barrier function. It has been found that gut microbiota members such as Bifidobacterium and lactobacillus have the ability to digest and inactivate gliadin peptides hence reducing their inflammatory effects in the gastrointestinal system.
Notice:Our products are intended for lab use only. For any other use, please contact us.
Chemical properties
Molecular weight:1,906 g/mol
Color/Form:Powder
Technical inquiry about: alpha-gliadin (58-73)
Please use instead the cart to request a quotation or an order
If you want to request a quotation or place an order, please instead add the desired products to your cart and then request a quotation or order from the cart. It is faster, cheaper, and you will be able to benefit from the available discounts and other advantages.