Product Information
Name:Ascomycin
Brand:Biosynth
Description:Ascomycin is an immunosuppressive macrolide, which is a product derived from the fermentation of the bacterium *Streptomyces hygroscopicus*. Its mode of action involves binding to the intracellular protein FK506-binding protein (FKBP), inhibiting the calcium-dependent signal transduction pathway that is crucial for T-cell activation. This interference with the immune response is achieved through the inhibition of calcineurin, thus preventing the dephosphorylation and nuclear translocation of nuclear factor of activated T-cells (NF-AT), a necessary step in the activation of genes required for T-cell proliferation.
Due to its immunosuppressive properties, ascomycin is primarily used in medical research and treatment to prevent organ transplant rejection and to manage autoimmune disorders. Its effects on selective immunomodulation make it a valuable compound for exploring therapeutic avenues in conditions such as psoriasis and atopic dermatitis. Ongoing studies delve into enhancing its clinical efficacy and delivery mechanisms, recognizing its potential to modulate immune responses with precision.
Notice:Our products are intended for lab use only. For any other use, please contact us.
Chemical properties
Molecular weight:792.01 g/mol
Formula:C43H69NO12
Purity:Min. 95%
Technical inquiry about: Ascomycin
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