4'-Demethylepipodophyllotoxin
CAS:
Ref. 3D-FD21027
25g
318.00€
50g
455.00€
100g
737.00€
250g
1,467.00€
500g
2,312.00€
Product Information
Name:4'-Demethylepipodophyllotoxin
Synonyms:
- (5R,5aR,8aR,9S)-9-Hydroxy-5-(4-hydroxy-3,5-dimethoxyphenyl)-5,8,8a,9-tetrahydrofuro[3',4':6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one
Brand:Biosynth
Description:4'-Demethylepipodophyllotoxin is a semisynthetic lignan, derived from the toxin podophyllotoxin, which is extracted from the roots and rhizomes of Podophyllum species, such as Podophyllum peltatum. The compound acts primarily as a topoisomerase II inhibitor. By binding to and stabilizing the enzyme-DNA complex, it prevents the re-ligation of DNA strands, which ultimately leads to breaks in the DNA and triggers apoptosis in rapidly dividing cancer cells.
This lignan has significant applications in oncology, primarily used as a precursor in the synthesis of chemotherapeutic agents like etoposide and teniposide. These derivatives exhibit enhanced solubility and bioavailability compared to the parent compound, making them more suitable for clinical use. They are particularly effective in the treatment of various cancers, including small cell lung cancer, testicular cancer, and lymphomas. Extensive research is ongoing to explore its potential in novel therapeutic regimens and its effectiveness in combination with other anticancer agents, aiming to improve patient outcomes through synergistic effects and reduced resistance.
Notice:Our products are intended for lab use only. For any other use, please contact us.
Chemical properties
Molecular weight:400.38 g/mol
Formula:C21H20O8
Color/Form:Powder
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