10-Hydroxycamptothecin
CAS:
Ref. 3D-FH16009
1g
317.00€
2g
460.00€
5g
619.00€
250mg
212.00€
500mg
254.00€
Product Information
Name:10-Hydroxycamptothecin
Brand:Biosynth
Description:10-Hydroxycamptothecin is an alkaloid, which is derived from the bark and stem of the Camptotheca acuminata tree, commonly known as the "Happy Tree." This compound is a potent topoisomerase I inhibitor. Its mode of action involves binding to the topoisomerase I-DNA complex, stabilizing it and thus preventing the re-ligation of DNA single-strand breaks. This interruption in the DNA replication process leads to DNA damage, ultimately triggering apoptosis in rapidly dividing cells.
10-Hydroxycamptothecin is primarily explored for its anticancer properties. It shows significant efficacy against various cancer cell lines, including those related to colorectal, ovarian, and lung cancers. Its unique mechanism of action, targeting the DNA processing enzymes, makes it a valuable compound in oncological research for developing chemotherapeutic agents. However, its clinical application is limited by solubility and stability challenges, necessitating further research into formulation and delivery methods to enhance its therapeutic potential and minimize side effects.
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Chemical properties
Molecular weight:364.35 g/mol
Formula:C20H16N2O5
Purity:Min. 95%
Color/Form:Powder
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