2-Hydroxy atorvastatin lactone
CAS:
Ref. 3D-FH23908
1mg
189.00€
2mg
303.00€
5mg
426.00€
10mg
632.00€
25mg
959.00€
Product Information
Name:2-Hydroxy atorvastatin lactone
Synonyms:
- 5-(4-Fluorophenyl)-N-(2-hydroxyphenyl)-2-(1-methylethyl)-4-phenyl-1-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-1H-p yrrole-3-carboxamide
Brand:Biosynth
Description:2-Hydroxyatorvastatin lactone is a prodrug of atorvastatin, which is an HMG-CoA reductase inhibitor. It is used to lower cholesterol and triglycerides in the blood. The drug is administered as a tablet, capsule, or liquid and can be taken with or without food. 2-Hydroxyatorvastatin lactone is metabolized by cytochrome P450 enzymes in the liver to produce active atorvastatin. This metabolism may be inhibited by other drugs that are also metabolized by cytochrome P450 enzymes, such as erythromycin and ketoconazole. 2-Hydroxyatorvastatin lactone has been shown to have an inhibition constant (Ki) of 0.5 μM for human liver microsomes and plasma concentrations of 1 μM or higher are required for therapeutic effect.
Notice:Our products are intended for lab use only. For any other use, please contact us.
Chemical properties
Molecular weight:556.62 g/mol
Formula:C33H33FN2O5
Purity:Min. 95%
Color/Form:Off-White Slightly Yellow Powder
InChI:InChI=1S/C33H33FN2O5/c1-20(2)31-30(33(40)35-26-10-6-7-11-27(26)38)29(21-8-4-3-5-9-21)32(22-12-14-23(34)15-13-22)36(31)17-16-25-18-24(37)19-28(39)41-25/h3-15,20,24-25,37-38H,16-19H2,1-2H3,(H,35,40)/t24-,25-/m1/s1
InChI key:InChIKey=MNECBMZJZFGTIK-JWQCQUIFSA-N
SMILES:CC(C)c1c(C(=O)Nc2ccccc2O)c(-c2ccccc2)c(-c2ccc(F)cc2)n1CC[C@@H]1C[C@@H](O)CC(=O)O1
Technical inquiry about: 2-Hydroxy atorvastatin lactone
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