Lapatinib ditosylate monohydrate
CAS:
Ref. 3D-FL24843
5g
189.00€
10g
303.00€
25g
462.00€
50g
632.00€
100g
959.00€
Product Information
Name:Lapatinib ditosylate monohydrate
Synonyms:
- N-[3-Chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[5-[[[2-(methylsulfonyl)ethyl]amino]methyl]-2-furanyl]-4-quinazolinamine bis(4-
Brand:Biosynth
Description:Inhibitor of EGFR (ErbB1) and HER2 (ErbB2) receptor tyrosine kinases. Used for sensitization of HER2-overexpressing cancer cells to radiation as well as chemotherapy to tamoxifen- and trastuzumab-resistant cell lines. The compound blocks signalling via Akt and mitogen-activated protein kinase (MAPK) pathways leading to reduced cell survival. In trastuzumab resistant cancer cells, it inhibits HER2 phosphorylation, prevents receptor ubiquitination and causes accumulation of inactive HER2 dimers on the cell surface.
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Chemical properties
Molecular weight:943.48 g/mol
Formula:C29H26ClFN4O4S•(C7H8O3S)2•H2O
Purity:Min. 95%
Technical inquiry about: Lapatinib ditosylate monohydrate
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