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1-Methyl-N-(9-methyl-9-azabicyclo[3.3.1]non-3-yl)-indazole-3-carboxamide
CAS:
Ref. 3D-FM137557
1g
258.00€
2g
457.00€
5g
906.00€
250mg
142.00€
500mg
175.00€
Product Information
Name:1-Methyl-N-(9-methyl-9-azabicyclo[3.3.1]non-3-yl)-indazole-3-carboxamide
Controlled Product
Synonyms:
- Granisetron
Brand:Biosynth
Description:1-Methyl-N-(9-methyl-9-azabicyclo[3.3.1]non-3-yl)-indazole-3-carboxamide is a chemical inhibitor of the 5HT2 receptor, which is responsible for regulating nausea and vomiting. It has been shown to have antiemetic properties, and can be used in chemotherapy to control nausea and vomiting. The 5HT2 receptor is coupled to Gs proteins and inhibits adenylyl cyclase activity, while 1MMAI binds to the 5HT2A receptor and blocks serotonin from binding. This prevents serotonin from activating Gq protein receptors, which are involved in the generation of intracellular calcium concentrations that lead to neurotransmitter release. 1MMAI also inhibits the activation of phospholipase C by serotonin, resulting in decreased levels of diacylglycerol (DAG) and inositol triphosphate (IP3). These changes inhibit plate
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Chemical properties
Molecular weight:312.41 g/mol
Formula:C18H24N4O
Purity:Min. 95%
Color/Form:White Off-White Powder
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