Picropodophyllin
CAS:
Ref. 3D-FP63882
25mg
212.00€
50mg
317.00€
100mg
397.00€
250mg
530.00€
500mg
754.00€
Product Information
Name:Picropodophyllin
Synonyms:
- (5R,5aS,8aR,9R)-5,8,8a,9-Tetrahydro-9-hydroxy-5-(3,4,5-trimethoxyphenyl)-furo[3',4':6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one
Brand:Biosynth
Description:Picropodophyllin is a semi-synthetic small molecule compound, which is derived from the natural podophyllotoxin isolated from the roots of Podophyllum species. It functions primarily as an insulin-like growth factor-1 receptor (IGF-1R) inhibitor, disrupting downstream signaling pathways that are essential for cellular proliferation and survival. By selectively inhibiting IGF-1R, picropodophyllin interferes with critical cellular processes, such as DNA synthesis and cell cycle progression, which are vital in oncogenic transformation.
The primary applications of picropodophyllin are in cancer research, particularly in studying the mechanisms of tumor growth and exploring therapeutic interventions. Its ability to halt the activity of IGF-1R makes it a valuable tool for investigating the role of this receptor in various malignancies, including breast cancer, leukemia, and sarcomas. Additionally, picropodophyllin is utilized in cellular biology studies to uncover signaling cascades related to growth factor receptors, providing insights into potential drug target pathways. By delving into the mechanistic aspects of IGF-1R inhibition, researchers can better understand the complexities of cancer biology and develop more targeted therapeutic approaches.
Notice:Our products are intended for lab use only. For any other use, please contact us.
Chemical properties
Molecular weight:414.41 g/mol
Formula:C22H22O8
Purity:Min. 95%
Color/Form:White Powder
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