(S)-(-)-Thalidomide
CAS:
Ref. 3D-FT28191
Product Information
Name:(S)-(-)-Thalidomide
Controlled Product
Synonyms:
- (S)-(-)-2-(2,6-Dioxo-3-piperidinyl)-1H-iso-indole-1,3(2H)-dione(S)-ThalidomideNSC 91730
Brand:Biosynth
Description:Thalidomide is a drug that is used to treat human immunodeficiency, but has been found to have some side effects. It is an immunomodulatory drug that alters the immune system by suppressing the production of cytokines such as TNF-α and IL-1β. Thalidomide inhibits the production of prostaglandins, which are inflammatory mediators. It also has been shown to be effective in treating erythema nodosum leprosum and Behçet's disease. The molecular structure of thalidomide contains two chiral centers: carbonyl group and chlorine. The (S) form is more active than its enantiomer (R). Thalidomide can cause serious adverse reactions, including peripheral neuropathy, constipation, hiccoughs, tachycardia, insomnia, dizziness, nausea and vomiting.
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Chemical properties
Molecular weight:258.23 g/mol
Formula:C13H10N2O4
Purity:Min. 95%
InChI:InChI=1S/C13H10N2O4/c16-10-6-5-9(11(17)14-10)15-12(18)7-3-1-2-4-8(7)13(15)19/h1-4,9H,5-6H2,(H,14,16,17)/t9-/m0/s1
InChI key:InChIKey=UEJJHQNACJXSKW-VIFPVBQESA-N
SMILES:O=C1CC[C@H](N2C(=O)c3ccccc3C2=O)C(=O)N1