Temafloxacin
CAS:
Ref. 3D-FT30403
Product Information
Name:Temafloxacin
Brand:Biosynth
Description:Temafloxacin is a broad-spectrum fluoroquinolone antibacterial agent that is used in the treatment of pulmonary, urinary tract, and soft tissue infections. Temafloxacin inhibits bacterial growth by binding to DNA-dependent RNA polymerase, thereby preventing transcription and replication. It has been shown to inhibit growth of gram-positive bacteria, such as Streptococcus pneumoniae, Enterococcus faecalis, and Staphylococcus aureus. This drug also has inhibitory properties against gram-negative bacteria such as Escherichia coli. Temafloxacin binds to the 50S ribosomal subunit of bacterial cells by competitive inhibition. This binding prevents the formation of an antibiotic-inhibitor complex with the enzyme cell wall synthesis that is required for cell wall biosynthesis, inhibiting protein synthesis and cell division.
Temafloxacin has been found to be toxic to experimental animals at high doses (
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Chemical properties
Molecular weight:417.38 g/mol
Formula:C21H18F3N3O3
Purity:Min. 95%
InChI:InChI=1S/C21H18F3N3O3/c1-11-9-26(5-4-25-11)19-8-18-13(7-16(19)24)20(28)14(21(29)30)10-27(18)17-3-2-12(22)6-15(17)23/h2-3,6-8,10-11,25H,4-5,9H2,1H3,(H,29,30)
InChI key:InChIKey=QKDHBVNJCZBTMR-UHFFFAOYSA-N
SMILES:CC1CN(c2cc3c(cc2F)c(=O)c(C(=O)O)cn3-c2ccc(F)cc2F)CCN1