

(R1)-(Tetrahydrofuran-2-yl)-5-fluorouracil
CAS:
Ref. 3D-FT76523


Product Information
Name:(R1)-(Tetrahydrofuran-2-yl)-5-fluorouracil
Synonyms:
- Tegafur
Brand:Biosynth
Description:(R1)-(Tetrahydrofuran-2-yl)-5-fluorouracil is a prodrug of 5-FU, which is a chemotherapeutic drug used to treat colorectal adenocarcinoma. It is converted in the body to 5-FU by esterases and glucuronidases, which inhibits DNA synthesis and cell division. (R1)-(Tetrahydrofuran-2-yl)-5-fluorouracil has been shown to have anticancer activity in treatment trials with multivariate logistic regression analysis and enzyme activities. The conversion of (R1)-(Tetrahydrofuran-2-yl)-5-fluorouracil into 5-FU can be inhibited by using P450 inhibitors such as ketoconazole and erythromycin, suggesting that this pharmacological agent may not be suitable for patients with liver or renal impairment.
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Chemical properties
Molecular weight:200.17 g/mol
Formula:C8H9FN2O3
Purity:Min. 95%
Color/Form:Powder