Product Information
Name:N-Debenzoyl-N-hexanoylpaclitaxel
Synonyms:
- Paclitaxel impurity C(-)-TaxuyunnanineTaxol C7,11-Methano-1H-cyclodeca[3,4]benz[1,2-b]oxete benzenepropanoic acid derivative
Brand:Biosynth
Description:N-Debenzoyl-N-hexanoylpaclitaxel (DHBPTx) is an analog of paclitaxel. It inhibits cell proliferation by binding to the diketone group at the C-10 position of baccatin III, which inhibits the synthesis of taxol and other natural products with a diketone group at this position. DHBPTx is effective against colorectal carcinoma cells in culture, but has not been tested in vivo. This drug has also been shown to be effective against breast cancer cells that express high levels of 10-deacetylase activity. It is metabolized into 10-deacetylbaccatin III, which binds to cellular protein kinase C and causes inhibition of mitosis and apoptosis. In addition, DHBPTx can be conjugated with other drugs such as doxorubicin or vincristine to increase their effectiveness.
Notice:Our products are intended for lab use only. For any other use, please contact us.
Chemical properties
Molecular weight:847.94 g/mol
Formula:C46H57NO14
Purity:Min. 95%
Technical inquiry about: N-Debenzoyl-N-hexanoylpaclitaxel
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