Product Information
Name:Candesartan N2-glucuronide
Brand:Biosynth
Description:Candesartan N-glucuronide is a metabolite of candesartan. It is produced by human UDP-glucuronosyltransferase, which belongs to the subfamily of uridine diphosphate (UDP)-glucuronosyltransferases. Candesartan N-glucuronide inhibits angiotensin II receptor type 1 (AT1) and has minimal effects on angiotensin II receptor type 2 (AT2). Candesartan N-glucuronide binds to the AT1 receptor and blocks its activation by angiotensin II. This binding inhibits the uptake of sodium ions into cells and causes an increase in potassium ion secretion, leading to vasodilation. Candesartan N-glucuronide also induces the expression of cytochrome P450 3A5, which results in increased metabolism of drugs such as paclitaxel.
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Chemical properties
Molecular weight:616.58 g/mol
Formula:C30H28N6O9
Purity:Min. 95%
Technical inquiry about: Candesartan N2-glucuronide
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