8-Chloroadenosine
CAS:
Ref. 3D-NC03343
10mg
212.00€
25mg
338.00€
50mg
497.00€
100mg
707.00€
250mg
1,005.00€
Product Information
Name:8-Chloroadenosine
Synonyms:
- 8-Chloro-D-adenosine
Brand:Biosynth
Description:8-Chloroadenosine is a potent inhibitor of apoptosis, which is the process by which cells die. It has been shown to inhibit cell growth in murine hepatoma cells and synergize with other cytotoxic agents. 8-Chloroadenosine inhibits the activity of bcl-2 protein and thus blocks the release of cytochrome c from mitochondria. This causes DNA damage by inhibiting DNA synthesis and protein synthesis, leading to apoptosis. 8-Chloroadenosine has also been shown to be an active inhibitor of cancer cells, especially myeloma cell lines. The response element for 8-chloroadenosine is located in the promoter region of the gene encoding cyclooxygenase 2 (COX-2), which encodes a protein that produces prostaglandins involved in inflammation and tumor growth. The concentration of camp in cancer tissues determines whether these cells will respond favorably or unfavorably to this drug.
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Chemical properties
Molecular weight:301.69 g/mol
Formula:C10H12ClN5O4
Purity:Min. 95%
Color/Form:Powder
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