Gemcitabine base
CAS:
Ref. 3D-ND04237
10g
341.00€
25g
636.00€
50g
963.00€
100g
1,453.00€
250g
2,652.00€
Product Information
Name:Gemcitabine base
Synonyms:
- 2-Deoxy-2',2'-difluorocytidine4-Amino-1-[3,3-difluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one2'-Deoxy-2',2'-difluor o-D-cytidine2',2'-Difluoro-2'-deoxycytidine
Brand:Biosynth
Description:Gemcitabine is a prodrug that is converted to 5-fluorouracil (5FU) in the body. It has been shown to inhibit the growth of bladder and pancreatic cancer cells by interfering with the synthesis of DNA. Gemcitabine inhibits DNA replication by binding to the epidermal growth factor receptor, which leads to cell death. Gemcitabine also acts as a competitive inhibitor of deoxycytidine kinase, which prevents the formation of deoxycytidine monophosphate from deoxyuridine monophosphate, preventing DNA replication. In addition, gemcitabine can activate apoptosis in some tumor cells by increasing levels of intracellular free calcium, which leads to activation of enzymes such as phospholipases and proteases that degrade proteins, lipids, and nucleic acids.
Notice:Our products are intended for lab use only. For any other use, please contact us.
Chemical properties
Molecular weight:263.2 g/mol
Formula:C9H11F2N3O4
Purity:Min. 98 Area-%
Color/Form:White Powder
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