GT1b-Ganglioside sodium
CAS:
Ref. 3D-OG03923
1mg
368.00€
2mg
523.00€
5mg
992.00€
10mg
1,460.00€
25mg
2,845.00€
Product Information
Name:GT1b-Ganglioside sodium
Synonyms:
- Cer-Glc-Gal(NeuAc-NeuAc)-GalNAc-Gal-NeuAcGT1b-Ganglioside
Brand:Biosynth
Description:GT1b (sodium salt) has a core tetrasaccharide structure (Galβ1,3GalNAcβ1,4Galβ1,4Glc) with two sialic acids (NeuAc) linked α2,3/α2,8 to the inner galactose residue, sialic acid (NeuAc) linked α2,3 to the terminal galactose residue and ceramide linked β to position 1 on the reducing terminal glucose residue (Ledeen, 2009). GT1b is one of the major gangliosides in neuronal and glial membranes, it interacts with the myelin-associated glycoprotein (MAG) and is essential for long-term axon-myelin stability. GT1b ganglioside also acts as a receptor for bacterial toxins, such as, tetanus and botulinum toxins (Nishik,i 1996), as well as for viruses, a few examples include: Merkel cell polyomavirus, JC virus, BK virus, norovirus, and others (Low, 2006).
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Chemical properties
Molecular weight:2,145.33 g/mol
Formula:C95H165N5O48·xNa
Color/Form:White Powder
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