Product Information
Name:MSH-Release Inhibiting Factor
Synonyms:
- Pro-Leu-Gly-NH2 • ½H2O
Brand:Biosynth
Description:MSH-Release Inhibiting Factor (MRIF) has been shown to be a potent inhibitor of the release of proinflammatory cytokines. It is derived from the acid methyl ester of mouse serum, and has been shown to inhibit the release of tumor necrosis factor-α (TNF-α) in animal studies. MRIF has also been shown to have anti-diabetic effects in mice. MRIF inhibits the production of inflammatory cytokines by blocking TNF-α at a molecular level. This protein binds to progesterone receptor and prevents it from interacting with its ligand, which is necessary for cancer cell growth. The expression system for this protein is E. coli, and it can be used as an immunosuppressant in animal studies.
MRIF also blocks TNF-α activity by inhibiting transcriptional activation of NFκB and AP-1, which are proteins that regulate gene expression.
Notice:Our products are intended for lab use only. For any other use, please contact us.
Chemical properties
Molecular weight:293.36 g/mol
Formula:C13H24N4O3H2O
Purity:Min. 95%
Technical inquiry about: MSH-Release Inhibiting Factor
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