Product Information
Name:SKLB4771 (FLT3-IN-1)
Brand:Biosynth
Description:SKLB4771 (FLT3-IN-1) is a selective small molecule inhibitor predominantly known for targeting FLT3, a receptor tyrosine kinase implicated in various hematological malignancies. Originating from a structure-based design and optimization process, this compound functions by competitively inhibiting the ATP-binding site of FLT3, thereby obstructing its autophosphorylation and subsequent downstream signaling cascades.
The primary mechanism of action for SKLB4771 involves the interruption of FLT3-driven proliferative and survival pathways, making it a valuable tool in probing the molecular underpinnings of FLT3-dependent cancers, such as acute myeloid leukemia (AML).
In preclinical studies, SKLB4771 has demonstrated efficacy in abrogating FLT3 signaling, leading to the suppression of leukemic cell proliferation and the induction of apoptosis. Its application extends to the exploration of FLT3-related oncogenic processes, aiding in the development of targeted therapeutic strategies. Further research on SKLB4771 may facilitate the advancement of novel interventions in FLT3-associated malignancies.
Notice:Our products are intended for lab use only. For any other use, please contact us.
Chemical properties
Molecular weight:537.66 g/mol
Formula:C25H27N7O3S2
Purity:Min. 95%
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