Product Information
Name:Wedelolactone
Synonyms:
- 5,11,12-Trihydroxy-7-methoxycoumestan
Brand:Biopurify
Description:Wedelolactone is a potent Î2-arrestin-biased G protein-coupled receptor-35 (GPR35) agonist, GPR35 has been shown to be a target of the asthma drugs cromolyn disodium and nedocromil sodium. Wedelolactone has anti-inflammatory, growth inhibitory, anti-cancer, anti-fibrotic, and pro-apoptotic effects. Wedelolactone stimulates ER genomic and non-genomic signalling pathways; it can significantly inhibit the activation of LX-2 cells, the underlying mechanisms of which included inducing Bcl-2 family involved apoptosis, up-regulating phosphorylated status of ERK and JNK expressions, and inhibiting NF-κB mediated activity.
Notice:Our products are intended for lab use only. For any other use, please contact us.
Chemical properties
Molecular weight:314.249
Formula:C16H10O7
Purity:95%~99%
InChI:InChI=1S/C16H10O7/c1-21-6-2-10(19)14-12(3-6)23-16(20)13-7-4-8(17)9(18)5-11(7)22-15(13)14/h2-5,17-19H,1H3
InChI key:InChIKey=XQDCKJKKMFWXGB-UHFFFAOYSA-N
SMILES:COc1cc(O)c2c(c1)oc(=O)c1c3cc(O)c(O)cc3oc21
Technical inquiry about: Wedelolactone
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