PROTAC CARM1/IKZF3 degrader-1
Ref. TM-T205337
10mg
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50mg
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Product Information
Name:PROTAC CARM1/IKZF3 degrader-1
Brand:Targetmol
Description:PROTAC CARM1/IKZF3 degrader-1 (Compound 074) inhibits CARM1, reducing the methylation level of its substrate BAF155. This PROTAC degrader works by degrading IKZF 1/3 via a CRBN-dependent mechanism. It suppresses MYC protein expression, thereby inhibiting the proliferation of various multiple myeloma cells. Additionally, PROTAC CARM1/IKZF3 degrader-1 can induce apoptosis in H929 cells and overcomes resistance to immunomodulatory drugs (IMiDs, such as pomalidomide). It is applicable for cancer and immunology research. (Pink: ligand for target protein CARM1/IKZF3 ligand 1; Active form of target protein ligand: EZM 2302; Black: linker; Blue: ligand for E3 ligase Cereblon Thalidomide 4-fluoride)
Notice:Our products are intended for lab use only. For any other use, please contact us.
Chemical properties
Molecular weight:896.43
Formula:C46H54ClN9O8
Color/Form:Solid
Technical inquiry about: PROTAC CARM1/IKZF3 degrader-1
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