Product Information
Name:PD-L1/HDAC6-IN-1
Brand:Targetmol
Description:PD-L1/HDAC6-IN-1 (Compound HP29) is an inhibitor targeting both PD-L1 and HDAC6, effectively disrupting the PD-L1/PD-1 interaction and inhibiting HDAC6 activity, with IC50 values of 26.8 nM and 69 nM, respectively. This compound enhances the cytotoxicity of Jurkat T cells against HepG2 cells, exhibiting an IC50 of 3.4 μM. In rats, PD-L1/HDAC6-IN-1 demonstrates favorable pharmacokinetics, showing a drug exposure level of 871.62 ng·h/mL, and displays antitumor activity in a B16-F10 xenograft mouse model.
Notice:Our products are intended for lab use only. For any other use, please contact us.
Chemical properties
Molecular weight:447.569
Formula:C27H33N3O3
Color/Form:Solid
Technical inquiry about: PD-L1/HDAC6-IN-1
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