5-HT1AR/5-HT6R ligand-1
Ref. TM-T205634
10mg
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50mg
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Product Information
Name:5-HT1AR/5-HT6R ligand-1
Brand:Targetmol
Description:5-HT1AR/5-HT6R ligand-1 (Compound PP13) functions as a ligand for the 5-HT receptor, demonstrating high affinity for 5-HT1AR, 5-HT6R, and 5-HT7R with Ki values of 19, 69, and 198 nM, respectively. In HEK293 cells, it inhibits cAMP production with EC50 values of 1535, 488, and 53 nM for these receptors. Additionally, 5-HT1AR/5-HT6R ligand-1 exhibits antiproliferative effects on several cancer cell lines, including 1321N1, U87MG, MCF7, and AsPC-1, with IC50 values of 9.6, 13.6, 19.3, and 14.6 μM, respectively. The compound also shows antagonistic activity towards the dopamine receptor D2R, with a Ki of 1903 nM.
Notice:Our products are intended for lab use only. For any other use, please contact us.
Chemical properties
Molecular weight:485.04
Formula:C25H29ClN4O2S
Color/Form:Solid
Technical inquiry about: 5-HT1AR/5-HT6R ligand-1
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