Product Information
Name:Halofuginone hydrochloride
Synonyms:
- RU-19110 hydrochloride
Brand:Targetmol
Description:Halofuginone hydrochloride (RU-19110), a derivative of Febrifugine, functions as a competitive inhibitor of prolyl-tRNA synthetase, displaying a Ki value of 18.3 nM. This compound effectively inhibits type-I collagen synthesis, providing therapeutic benefits in osteoarthritis (OA) by impeding TGF-β signaling. Additionally, it serves as a potent pulmonary vasodilator, mainly through the activation of Kv channels and the inhibition of various calcium channels including voltage-gated, receptor-operated, and store-operated ones. Beyond its vascular effects, Halofuginone hydrochloride exhibits a broad spectrum of biological activities, including anti-malarial, anti-inflammatory, anti-cancer, and anti-fibrotic properties, supported by multiple studies.
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Chemical properties
Molecular weight:451.14
Formula:C16H18BrCl2N3O3
Color/Form:Solid
Technical inquiry about: Halofuginone hydrochloride
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