Product Information
Name:(1S,4R)-cis-4-Amino-2-cyclopentene-1-methanol D-Tartrate
Controlled Product
Synonyms:
- [(1S,4R)-4-aminocyclopent-2-en-1-yl]methanol;(2S,3S)-2,3-dihydroxybutanedioic acid
Brand:TRC
Description:Impurity Abacavir - In House Impurity
Applications (1S,4R)-cis-4-Amino-2-cyclopentene-1-methanol D-Tartrate (Abacavir - In House Impurity) is an intermediate of Abacavir (A104990). Abacavir is a carbocyclic 2'-deoxyguanosine nucleoside reverse transcriptase inhibitor and an anti-HIV drug used to treat HIV infection (1). Intracellular enzymes convert Abacavir to its active form, carbovir-triphosphate (CBV-TP), which then selectively inhibits HIV reverse transcriptase by incorporating into viral DNA (2). Abacavir is metabolized in the liver by uridine diphosphate glucuronyltransferase and alcohol dehydrogenase resulting in inactive glucuronide and carboxylate metabolites, respectively.
References (1) Jackson, A., et al.: Antivir Ther. 17, 19 (2012) (2) Yuen, G. J., et al.: Clin Pharmacokinet. 47, 351 (2008)
Notice:Our products are intended for lab use only. For any other use, please contact us.
Chemical properties
Molecular weight:263.24
Formula:C6H11NO·C4H6O6
Color/Form:Neat
InChI:InChI=1S/C6H11NO.C4H6O6/c7-6-2-1-5(3-6)4-8;5-1(3(7)8)2(6)4(9)10/h1-2,5-6,8H,3-4,7H2;1-2,5-6H,(H,7,8)(H,9,10)/t5-,6+;1-,2-/m10/s1
InChI key:InChIKey=LTSTZOJHLZNDFG-ZGMNSGLWSA-N
SMILES:N[C@H]1C=C[C@@H](CO)C1.O=C(O)[C@@H](O)[C@H](O)C(=O)O
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