Product Information
Name:1-(4-Aminophenyl)cyclopentanecarbonitrile-d8
Controlled Product
Synonyms:
- 1-(4-aminophenyl)-2,2,3,3,4,4,5,5-octadeuteriocyclopentane-1-carbonitrile
Brand:TRC
Description:Applications 1-(4-Aminophenyl)cyclopentanecarbonitrile-d8 is an intermediate used in the synthesis of Apatinib-d8 Hydrochloride (A726152), which is a labelled Apatinib (A726150). Apatinib is an orally available, small molecule multitargeted tyrosine kinase inhibitor. Apatinib selectively inhibits the vascular endothelial growth factor receptor-2 (VEGFR2). Apatinib functions by inhibiting VEGF-mediated endothelial cell migration and proliferation thus blocking new blood vessel formation in tumor tissue. Recent studies have shown that Apatinib enhances the efficacy of conventional chemotherapeutical drugs in side population (SP) cells and ABCB1-overexpressing leukemia cells.
References Mi, Y. et al.: Cancer Res., 70, 7981 (2010); Tong, X.Z. et al.: Biochem. Pharmacol., 83, 586 (2012); Ding, J, et al.: J. Chrom B Anal. Technol. Biomed. Life Sci., 895, 108 (2012);
Notice:Our products are intended for lab use only. For any other use, please contact us.
Chemical properties
Molecular weight:194.302
Formula:C12D8H6N2
Color/Form:Neat
InChI:InChI=1S/C12H14N2/c13-9-12(7-1-2-8-12)10-3-5-11(14)6-4-10/h3-6H,1-2,7-8,14H2/i1D2,2D2,7D2,8D2
SMILES:[2H]C1([2H])C([2H])([2H])C([2H])([2H])C(C#N)(c2ccc(N)cc2)C1([2H])[2H]
Technical inquiry about: 1-(4-Aminophenyl)cyclopentanecarbonitrile-d8
Please use instead the cart to request a quotation or an order
If you want to request a quotation or place an order, please instead add the desired products to your cart and then request a quotation or order from the cart. It is faster, cheaper, and you will be able to benefit from the available discounts and other advantages.