Product Information
Name:tert-Butyl 4-Bromo-2-fluorobenzoate
Controlled Product
Synonyms:
- 2-Methylpropan-2-yl 4-bromo-2-fluorobenzoate
- 4-Bromo-2-fluoro-benzoic Acid 1,1-Dimethylethyl Ester
Brand:TRC
Description:Applications tert-Butyl 4-Bromo-2-fluorobenzoate is an intermediate of enzalutamide (M199800). Enzalutamide is an androgen-receptor antagonist that blocks androgens from binding to the androgen receptor and prevents nuclear translocation and co-activator recruitment of the ligand-receptor complex. MDV 3100 has also been shown to induce tumor cell apoptosis, and has no agonist activity. MDV 3100 is a candidate for the treatment of castration-resistant prostate cancer.
References Scher, H.I. et al.: Lancet, 375, 1437 (2010); Bellmunt, J. et al.: Ther. Adv. Med. Oncol., 2, 189 (2010); Ryan, C.J. et al.: J. Clin. Oncol., 29, 3651 (2011);
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Chemical properties
Molecular weight:275.11
Formula:C11H12BrFO2
Color/Form:Neat
InChI:InChI=1S/C11H12BrFO2/c1-11(2,3)15-10(14)8-5-4-7(12)6-9(8)13/h4-6H,1-3H3
InChI key:InChIKey=ZPGZHSAOCVWZMR-UHFFFAOYSA-N
SMILES:CC(C)(C)OC(=O)c1ccc(Br)cc1F
Technical inquiry about: tert-Butyl 4-Bromo-2-fluorobenzoate
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