tert-Butyl ((S)-4-Methyl-1-((R)-2-methyloxiran-2-yl)-1-oxopentan-2-yl)carbamate
CAS:
Ref. TR-B809210
1mg
166.00€
10mg
226.00€
50mg
398.00€
Product Information
Name:tert-Butyl ((S)-4-Methyl-1-((R)-2-methyloxiran-2-yl)-1-oxopentan-2-yl)carbamate
Controlled Product
Synonyms:
- N-[(1S)-3-Methyl-1-[[(2R)-2-methyl-2-oxiranyl]carbonyl]butyl]carbamic Acid 1,1-Dimethylethyl Ester
- [(1S)-3-Methyl-1-[[(2R)-2-methyloxiranyl]carbonyl]butyl]carbamic Acid 1,1-Dimethylethyl Ester
- (2R)-2-[(2S)-2-(tert-Butoxycarbonylamino)-4-methylpentanoyl]-2-methyloxirane
Brand:TRC
Description:Applications tert-Butyl ((S)-4-Methyl-1-((R)-2-methyloxiran-2-yl)-1-oxopentan-2-yl)carbamate is an intermediate of Carfilzomib (C183460) which is a second-generation proteasome inhibitor that is used as a treatment in relapsed and refractory multiple myeloma.
References Wang, P., et al.: Process for preparation of carfilzomib, China Patent 2015010436, Jan 29, 2015; Fostier, K., et al.: Oncotargets. Therap., 5, 237 (2012); Geurink, P.P., et al.: J. Med. Chem., 56, 1262 (2013); McCormack, P.L., et al.: Drugs., 72, 2023 (2012)
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Chemical properties
Molecular weight:271.35
Formula:C14H25NO4
Color/Form:Neat
InChI:InChI=1S/C14H25NO4/c1-9(2)7-10(11(16)14(6)8-18-14)15-12(17)19-13(3,4)5/h9-10H,7-8H2,1-6H3,(H,15,17)/t10?,14-/m1/s1
InChI key:InChIKey=DDMPMIMTLBGEHT-LNUXAPHWSA-N
SMILES:CC(C)CC(NC(=O)OC(C)(C)C)C(=O)[C@@]1(C)CO1
Technical inquiry about: tert-Butyl ((S)-4-Methyl-1-((R)-2-methyloxiran-2-yl)-1-oxopentan-2-yl)carbamate
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