- Natural Products and Phytochemicals by Botanical Origin
- Phytochemicals
- Inhibitor Enzymes
- Angiogenesis
- Toxicology
Product Information
Name:Celastrol
Controlled Product
Synonyms:
- 24,25,26-Trinoroleana-1(10),3,5,7-tetraen-29-oic acid
- 3-hydroxy-9,13-dimethyl-2-oxo-
- (9ß,13a,14ß,20a)-
- 24-Nor-D:A-friedooleana-1(10),3,5,7-tetraen-29-oic acid
- 3-hydroxy-2-oxo- (7CI,8CI)
- D:A-Friedo-24-noroleana-1(10),3,5,7-tetraen-29-oic acid
- 3-hydroxy-2-oxo-
- (20a)-
- (9ß,13a,14ß,20a)-3-Hydroxy-9,13-dimethyl-2-oxo-24,25,26-trinoroleana-1(10),3,5,7-tetraen-29-oic acid
- 2-Picenecarboxylic acid
- 1,2,3,4,4a,5,6,6a,11,12b,13,14,14a,14b-tetradecahydro-10-hydroxy-2,4a,6a,9,12b,14a-hexamethyl-11-oxo-
- See more synonyms
Brand:TRC
Description:Applications An antioxidant natural product which inhibits the growth of human glioma xenografts in nude mice through suppressing VEGFR expression. Used for clinical treatment for rheumatoid arthritis, was demonstrated to have antiangiogenic activity, and be inhibitory against mice tumor growth by a few recent studies. Celastrol also has been shown to have the power to kill tumor cells and can work as an anticarcinogen. Celastrol is also a leptin sensitizer with the potential to reduce weight in obesity (see W499200).
References Senger, D., et al.: Science, 219, 983 (1983), Folkman, J., et al.: Nature, 1, 27 (1995), He, W., et al.: Bioorg. Med. Chem. Lett., 8, 3659 (1998), Grosios, K., et al.: Inflamm. Res., 53, 133 (2004), Yang, H., et al.: Cancer Res., 66, 4758 (2006); AAPS Newsmagazine p. 17, July 2016; Chem. and Eng. News p. 6, Aug. 8, 2016
Notice:Our products are intended for lab use only. For any other use, please contact us.
Chemical properties
Molecular weight:450.61
Formula:C29H38O4
Color/Form:Neat
InChI:InChI=1S/C29H38O4/c1-17-18-7-8-21-27(4,19(18)15-20(30)23(17)31)12-14-29(6)22-16-26(3,24(32)33)10-9-25(22,2)11-13-28(21,29)5/h7-8,15,22,31H,9-14,16H2,1-6H3,(H,32,33)/t22-,25-,26-,27+,28-,29+/m1/s1
InChI key:InChIKey=HADKVWSBPVYWSP-HMCFYJSVSA-N
Technical inquiry about: Celastrol
Please use instead the cart to request a quotation or an order
If you want to request a quotation or place an order, please instead add the desired products to your cart and then request a quotation or order from the cart. It is faster, cheaper, and you will be able to benefit from the available discounts and other advantages.