4-(4,4-Dimethyl-2,5-dioxo-1-imidazolidinyl)-2-(trifluoromethyl)benzonitrile
CAS:
Ref. TR-D143780
100mg
693.00€
250mg
1,633.00€
500mg
2,594.00€
Product Information
Name:4-(4,4-Dimethyl-2,5-dioxo-1-imidazolidinyl)-2-(trifluoromethyl)benzonitrile
Controlled Product
Synonyms:
- 4-(4,4-Dimethyl-2,5-dioxoimidazolidin-1-yl)-2-trifluoromethylbenzonitrile
- RU 56279
Brand:TRC
Description:Applications 4-(4,4-Dimethyl-2,5-dioxo-1-imidazolidinyl)-2-(trifluoromethyl)benzonitrile is an intermediate in the synthesis of Oxo-MDV 3100 (Oxo-enzalutamide) (O857800), which is an impurity of Enzalutamide (M199800), which is an androgen-receptor antagonist that blocks androgens from binding to the androgen receptor and prevents nuclear translocation and co-activator recruitment of the ligand-receptor complex. Enzalutamide has been shown to induce tumor cell apoptosis, and is used for the treatment of castration-resistant prostate cancer.
References Scher, H.I. et al.: Lancet, 375, 1437 (2010); Bellmunt, J. et al.: Ther. Adv. Med. Oncol., 2, 189 (2010); Ryan, C.J. et al.: J. Clin. Oncol., 29, 3651 (2011); Ma, X., et al.: J. Pharm. Biomed. Anal., 131, 436 (2016);
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Chemical properties
Molecular weight:297.23
Formula:C13H10F3N3O2
Color/Form:Neat
InChI:InChI=1S/H3N/h1H3
InChI key:InChIKey=QGZKDVFQNNGYKY-UHFFFAOYSA-N
SMILES:CC1(C)NC(=O)N(c2ccc(C#N)c(C(F)(F)F)c2)C1=O
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