Product Information
Name:N-Desmethyl Clozapine
Controlled Product
Synonyms:
- Clozapine Imp. C (EP),8-Chloro-11-(1-piperazinyl)-5H-dibenzo[B,E][1,4]diazepine
- 8-Chloro-11-(piperazin-1-yl)-5H-dibenzo[b,e][1,4]diazepine
- Desmethylclozapine
- Norclozapine
- Clozapine Impurity C
Brand:TRC
Description:Applications N-Desmethyl Clozapine is a metabolite of Clozapine (C587500). N-Desmethyl Clozapine is a potent, allosteric agonist at human M1 receptors and is able to potentiate hippocampal NMDA receptor currents through M1 receptor activation.
References Sur, C., et al.: Proc. Nat. Acad. Sci. U. S. A., 100, 13674 (2003); Kuoppamaki, M. et al.: Eur. J. Pharm. Mol. Pharm. Sect., 245, 179 (1993); Olessen, O.V., et al.: J. Chromatog., 622, 39 (1993); Pirmohamed, M., et al.: J. Pharmacol. Exp. Ther., 272, 984 (1995)
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Chemical properties
Molecular weight:312.80
Formula:C17H17ClN4
Color/Form:Light Yellow
InChI:InChI=1S/C17H17ClN4/c18-12-5-6-15-16(11-12)21-17(22-9-7-19-8-10-22)13-3-1-2-4-14(13)20-15/h1-6,11,19-20H,7-10H2
InChI key:InChIKey=JNNOSTQEZICQQP-UHFFFAOYSA-N
SMILES:Clc1ccc2c(c1)N=C(N1CCNCC1)c1ccccc1N2
Technical inquiry about: N-Desmethyl Clozapine
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