Des[2’-(1H-tetrazol-5-yl)] 2-Cyanolosartan

CAS:
114772-55-3

Ref. TR-D297670

5g

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500mg

281.00€

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Salts and Derivatives of Active Pharmaceutical Ingredients (API)

Product Information

Name:Des[2’-(1H-tetrazol-5-yl)] 2-Cyanolosartan

Controlled Product

Synonyms:

4'-[[2-butyl-4-chloro-5-(hydroxymethyl)-1H-imidazol-1-yl]methyl]- [1,1'-Biphenyl]-2-carbonitrile
2-Butyl-4-chloro-1-[(2'-cyanobiphenyl-4-yl)methyl]-5-hydroxymethylimidazole
4'-(2-Butyl-4-chloro-5-hydroxymethyl-1H-imidazol-1-yl)-1,1'-biphenyl-2-carbonitrile

Brand:TRC

Description:Applications Des[2’-(1H-tetrazol-5-yl)] 2-Cyanolosartan is a derivative of Losartan Potassium (L470500), a an angiotensin II antagonist and is commonly used to significantly reduce risk of new onset atrial fibrillation and associated stroke in high-risk patients. References Madasu, S., et al.: Org. Process Res. Dev., 16, 2025 (2012); Pitt, B., et al.: The Lancet, 355, 1582 (2000); Wachtell, K., et al.: J. Am. Coll. Cardiol., 45, 712 (2005)

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Chemical properties

Molecular weight:379.88

Formula:C₂₂H₂₂ClN₃O

Color/Form:Neat

InChI:InChI=1S/C22H22ClN3O/c1-2-3-8-21-25-22(23)20(15-27)26(21)14-16-9-11-17(12-10-16)19-7-5-4-6-18(19)13-24/h4-7,9-12,27H,2-3,8,14-15H2,1H3

InChI key:InChIKey=ABCNKIQTAGPXAQ-UHFFFAOYSA-N

SMILES:CCCCc1nc(Cl)c(CO)n1Cc1ccc(-c2ccccc2C#N)cc1

Technical inquiry about: Des[2’-(1H-tetrazol-5-yl)] 2-Cyanolosartan

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