Product Information
Name:Dexamethasone 23-Dimorpholinophosphinate-D5
Controlled Product
Synonyms:
- 2-((8S,9R,10S,11S,13S,14S,16R,17R)-9-fluoro-11,17-dihydroxy-10,13,16-trimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-17-yl-4,6,6-d3)-2-oxoethyl-1,1-d2 dimorpholinophosphinate
Brand:TRC
Description:Applications Dexamethasone 23-Dimorpholinophosphinate-D5 is an intermediate in the synthesis of Dexamethasone Phosphate-D5 (Major) (D298837), which is the labeled form of Dexamethasone Phosphate (D298835), which is the pro-drug of Dexamethasone (D298800), an anti-inflammatory glucocorticoid. It was found that liposomal DXM-P inhibited both chronic inflammation and joint destruction, whereas free DXM-P failed to prevent joint destruction.
References Kodelja, V., et al.: J. Immunol., 160, 1411 (1998), Metselaar, J., et al.: Arthritis Rheum., 48, 2059 (2003), Buttgereit, F., et al.: Arthritis Rheum., 50, 3408 (2004), Martinez, F., et al.: Front Biosci., 13, 453 (2008),
Notice:Our products are intended for lab use only. For any other use, please contact us.
Chemical properties
Molecular weight:615.68
Formula:C30H39D5FN2O8P
Color/Form:Neat
InChI:InChI=1S/C30H44FN2O8P/c1-20-16-24-23-5-4-21-17-22(34)6-7-27(21,2)29(23,31)25(35)18-28(24,3)30(20,37)26(36)19-41-42(38,32-8-12-39-13-9-32)33-10-14-40-15-11-33/h6-7,17,20,23-25,35,37H,4-5,8-16,18-19H2,1-3H3/t20-,23+,24+,25+,27+,28+,29+,30+/m1/s1/i4D2,17D,19D2
InChI key:InChIKey=RNVQHKJBDRJEFZ-KHHDSCCQSA-N
SMILES:[2H]C1=C2C([2H])([2H])C[C@H]3[C@@H]4C[C@@H](C)[C@](O)(C(=O)C([2H])([2H])OP(=O)(N5CCOCC5)N5CCOCC5)[C@@]4(C)C[C@H](O)[C@]3(F)[C@@]2(C)C=CC1=O
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