(Z)-4-Hydroxy-N-desmethyl Tamoxifen (contains up to 10% E isomer)
CAS:
Ref. TR-H938500
1mg
539.00€
5mg
2,267.00€
500µg
313.00€
Product Information
Name:(Z)-4-Hydroxy-N-desmethyl Tamoxifen (contains up to 10% E isomer)
Controlled Product
Synonyms:
- 4-[(Z)-1-[4-[2-(methylamino)ethoxy]phenyl]-2-phenylbut-1-enyl]phenol
Brand:TRC
Description:Stability Light Sensitive, Temperature Sensitive
Applications A novel active metabolite of the anti-cancer drug Tamoxifen (T006000). It showed potent ER binding property, blocked estrogen stimulated growth of breast cancer cell and half maximal inhibition of estrogen responsive gene expression in ER pos. human breast cancer cell line.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Furr, B., et al.: Pharmacol. Ther., 25, 127 (1984), Leonessa, F., et al.: Cancer Res., 54, 441 (1994), Stearns, V., et al.: Lancet, 360, 1851 (2002), Rae, J., et al.: Pharmacogenetics, 13, 501 (2003),
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Chemical properties
Molecular weight:373.49
Formula:C25H27NO2
Color/Form:Neat
InChI:InChI=1S/C25H27NO2/c1-3-24(19-7-5-4-6-8-19)25(20-9-13-22(27)14-10-20)21-11-15-23(16-12-21)28-18-17-26-2/h4-16,26-27H,3,17-18H2,1-2H3/b25-24-
InChI key:InChIKey=MHJBZVSGOZTKRH-IZHYLOQSSA-N
SMILES:CC/C(=C(\c1ccc(O)cc1)c1ccc(OCCNC)cc1)c1ccccc1
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