Isopropyl N-(Hydroxyphenoxyphosphinyl)alaninate Sodium Salt
CAS:
Ref. TR-I824640
10g
1,572.00€
Product Information
Name:Isopropyl N-(Hydroxyphenoxyphosphinyl)alaninate Sodium Salt
Controlled Product
Synonyms:
- N-(Hydroxyphenoxyphosphinyl)-L-alanine 1-Methylethyl Ester Sodium Salt
- (2S)-Isopropyl 2-((Hydroxy(phenoxy)phosphoryl)amino)propanoate Sodium Salt
Brand:TRC
Description:Applications Isopropyl N-(Hydroxyphenoxyphosphinyl)alaninate Sodium Salt is an impurity of Sofosbuvir (P839640), a prodrug that is metabolized to the active antiviral agent 2'-deoxy-2'-α-fluoro-β-C-methyluridine-5'-monophosphate and is currently being investigated in phase 3 clinical trials for the treatment of hepatitis C. Studies have profiled PSI-7977 as a nucleotide inhibitor of hepatitis C virus, exerting selective inhibitory effects towards HCV NS5B polymerase.
References Lam, A.M.,et al.: Antimicrob. Agents. Chemotherapy., 56, 3359 (2012); Lam, A.M., et al.: J. Virol., 85, 12334 (2011); Sofia, M.J., et al.: J. Medn. Chem., 53, 7202 (2010);
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Chemical properties
Molecular weight:309.23
Formula:C12H17NNaO5P
Color/Form:Neat
InChI:InChI=1S/C12H18NO5P.Na/c1-9(2)17-12(14)10(3)13-19(15,16)18-11-7-5-4-6-8-11;/h4-10H,1-3H3,(H2,13,15,16);/q;+1/p-1/t10-;/m0./s1
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