1-(5-Isoquinolinesulfonyl)-1H-hexahydro-1,4-diazepine, Dihydrochloride
CAS:
Ref. TR-I882200
25mg
186.00€
Product Information
Name:1-(5-Isoquinolinesulfonyl)-1H-hexahydro-1,4-diazepine, Dihydrochloride
Controlled Product
Synonyms:
- HA1077
- Fasudil Dihydrochloride
Brand:TRC
Description:Applications A potent calcium antagonist vasodilator which is considered to act by employing different mechanisms from the usual calcium channel blockers since it inhibits (1) calcium ionophore A23187 induced contraction in arterial strips and (2) phenylephrine induced contraction in calcium free media suggesting that its site of action is in the intracellular space. Also reported to potently inhibit Rho-associated Kinase (ROCK IC50= 10.7 uM).
References Hidaka, H., et al.: Acta Nurochir. (Wien), 90 (1988) Sward., K., el a.: J. Physiol., 522, 33 (2000),
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Chemical properties
Molecular weight:364.29056
Formula:C14H17N3O2SHCl
Color/Form:Neat
InChI:InChI=1S/C14H17N3O2S.2ClH/c18-20(19,17-9-2-6-15-8-10-17)14-4-1-3-12-11-16-7-5-13(12)14;;/h1,3-5,7,11,15H,2,6,8-10H2;2*1H
InChI key:InChIKey=NGOGFTYYXHNFQH-UHFFFAOYSA-N
SMILES:O=S(=O)(c1cccc2cnccc12)N1CCCNCC1
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