- Food Industry Standards
- APIs for research and impurities
- Apoptosis
- Miscellaneous Organic Molecules with Isotopical Substitutions
- Cancer Research
Product Information
Name:MDV 3100-d3
Controlled Product
Synonyms:
- 4-[3-[4-Cyano-3-(trifluoromethyl)phenyl]-5,5-dimethyl-4-oxo-2-thioxo-1-imidazolidinyl]-2-fluoro-N-(methyl-d3)benzamide
- Enzalutamide-d3
Brand:TRC
Description:Applications Labelled MDV 3100. MDV 3100 is an androgen-receptor antagonist that blocks androgens from binding to the androgen receptor and prevents nuclear translocation and co-activator recruitment of the ligand-receptor complex. MDV 3100 has also been shown to induce tumor cell apoptosis, and has no agonist activity. MDV 3100 is a candidate for the treatment of castration-resistant prostate cancer.
References Scher, H.I. et al.: Lancet, 375, 1437 (2010); Bellmunt, J. et al.: Ther. Adv. Med. Oncol., 2, 189 (2010); Ryan, C.J. et al.: J. Clin. Oncol., 29, 3651 (2011);
Notice:Our products are intended for lab use only. For any other use, please contact us.
Chemical properties
Molecular weight:467.45
Formula:C21H13D3F4N4O2S
Color/Form:Neat
SMILES:[2H]C([2H])([2H])NC(=O)c1ccc(N2C(=S)N(c3ccc(C#N)c(C(F)(F)F)c3)C(=O)C2(C)C)cc1F
Technical inquiry about: MDV 3100-d3
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