Product Information
Name:N6-Methyladenosine
Controlled Product
Synonyms:
- 6-Methyladenosine
- N-methyladenosine
- 6-Methylamino-9-ß-D-ribofuranosylpurine
- 6-Methylaminopurine D-riboside
- 6-Methylaminopurine ribonucleoside
- 6-Methylaminopurine riboside
- 9-ß-D-Ribofuranosyl-N6-methylaminopurine
- N-Methyladenosine
- NSC 29409
Brand:TRC
Description:Applications N6-Methyladenosine is the most common internal modification of eukaryotic mRNA. The result of this modification is specifically recognized mRNA in the cytoplasm which regulates mRNA stability.N6-Methyladenosine is made when a protein complex containin the writer enzyme METTL3 adds a methyl group to adenosine. Two different eraser enzymes ALKBH5 and FTO can remove a methyl group to turn m6A bach into adenosine.
References Miura, G. et al.: Nat. Chem. Biol., 11, 903 (2015); Deng, X. et al.: Nucl. Acids Res., 43, 6557 (2015); Chem. and Eng. News, p.35, Feb. 18, 2019
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Chemical properties
Molecular weight:281.27
Formula:C11H15N5O4
Color/Form:Off-White
InChI:InChI=1S/C11H15N5O4/c1-12-9-6-10(14-3-13-9)16(4-15-6)11-8(19)7(18)5(2-17)20-11/h3-5,7-8,11,17-19H,2H2,1H3,(H,12,13,14)/t5-,7-,8-,11-/m1/s1
InChI key:InChIKey=VQAYFKKCNSOZKM-IOSLPCCCSA-N
SMILES:CNc1ncnc2c1ncn2[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O
Technical inquiry about: N6-Methyladenosine
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