Product Information
Name:Romidepsin-d8
Controlled Product
Synonyms:
- (1R,4S,7Z,10R,16E)-4-deuterio-7-ethylidene-4-(1,1,1,2,3,3,3-heptadeuteriopropan-2-yl)-21-propan-2-yl-2-oxa-12,13-dithia-5,8,20,23-tetrazabicyclo[8.7.6]tricos-16-ene-3,6,9,19,22-pentone
Brand:TRC
Description:Applications Labelled Romidepsin (R425060). Romidepsin is a histone deacetylase inhibitor that can alter chromatin structure and gene transcription leading to multiple changes in cellular protein production. This may result in cell cycle arrest and tumor growth inhibition. Romidepsin has shown anti-proliferative activity in vitro against multiple mouse and human tumor cell lines and in vivo in human tumor xenograft models. Romidepsin can be administered with a second agent, such as a cytotoxic agent, a steroidal agent, a proteasome inhibitor, or a kinase inhibitor.
References Ueda, H., et al.: J. Antibiot., 47, 301 (1994), Weidle, U., et al.: Anticancer Res., 20, 1471 (2000), Kitazono, M., et al.: Cancer Res., 61, 6328 (2001), Sandor, V., et al.: Clin. Cancer Res., 8, 718 (2002),
Notice:Our products are intended for lab use only. For any other use, please contact us.
Chemical properties
Molecular weight:548.745
Formula:C24D8H28N4O6S2
Color/Form:Neat
InChI:InChI=1S/C24H36N4O6S2/c1-6-16-21(30)28-20(14(4)5)24(33)34-15-9-7-8-10-35-36-12-17(22(31)25-16)26-23(32)19(13(2)3)27-18(29)11-15/h6-7,9,13-15,17,19-20H,8,10-12H2,1-5H3,(H,25,31)(H,26,32)(H,27,29)(H,28,30)/b9-7+,16-6-/t15-,17-,19?,20-/m0/s1/i4D3,5D3,14D,20D
InChI key:InChIKey=OHRURASPPZQGQM-JYUKDPTESA-N
SMILES:[2H]C([2H])([2H])C([2H])(C([2H])([2H])[2H])[C@]1([2H])NC(=O)/C(=C/C)NC(=O)[C@@H]2CSSCC/C=C/[C@@H](CC(=O)NC(C(C)C)C(=O)N2)OC1=O
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