Product Information
Name:RTI-336
Synonyms:
- (1R,2S,3S,5S)-3-(4-Chlorophenyl)-8-methyl-2-[3-(4-methylphenyl)-5-isoxazolyl]-8-azabicyclo[3.2.1]octane Hydrochloride
- [1R-(exo,exo)]-3-(4-Chlorophenyl)-8-methyl-2-[3-(4-methylphenyl)-5-isoxazolyl]-8-azabicyclo[3.2.1]octane Hydrochloride
- RTI 4229-336
Brand:TRC
Description:Applications RTI-336 is a a phenyltropane cocaine analog that acts selective dopamine reuptake inhibitor (1,2,3). RTI-336 binds to the dopamine transporter with around 20 times the affinity of cocaine but produces relatively mild stimulant effects. RTI-336 is a potential candidate for pharmacotherapy for treating cocaine addiction.
References (1) Carroll, F.I. et al.: AAPS J., 8, E196 (2006) (2) Czoty, P.W. et al.: Pharmacol. Biochem. Behav., 96, 274 (2010) (3) Carroll, F.I. et al.: Eur. J. Pharmacol., 553, 149 (2006)
Notice:Our products are intended for lab use only. For any other use, please contact us.
Chemical properties
Molecular weight:429.382
Formula:C24H25ClN2O·HCl
Color/Form:Neat
InChI:/h3-10,14,19-20,22,24H,11-13H2,1-2H3, InChI=1S/C24H25ClN2O.ClH/c1-15-3-5-17(6-4-15)21-14-23(28-26-21)24-20(16-7-9-18(25)10-8-16)13-19-11-12-22(24)27(19)2, 1H/t19-,20+,22+,24-, /m0./s1
InChI key:InChIKey=IZMZEMAKFSYLMD-SXBQIKTFSA-N
SMILES:Cc1ccc(-c2cc([C@H]3[C@@H](c4ccc(Cl)cc4)C[C@@H]4CC[C@H]3N4C)on2)cc1.Cl
Technical inquiry about: RTI-336
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