CAS 127-07-1: Hidroxiureia
Descrição:
Hidroxiureia, com o número CAS 127-07-1, é um composto químico que atua como agente antineoplásico, utilizado principalmente no tratamento de certos cânceres, como leucemia mieloide crônica e cânceres de cabeça e pescoço, bem como no manejo da doença falciforme. É um sólido cristalino branco que é solúvel em água e apresenta uma fórmula molecular de C₄H₈N₂O₂. Hidroxiureia funciona como um inibidor da ribonucleotídeo redutase, que interrompe a síntese de DNA ao impedir a conversão de ribonucleotídeos em desoxirribonucleotídeos, inibindo assim a proliferação celular. O composto também é conhecido por sua capacidade de aumentar os níveis de hemoglobina fetal em pacientes com doença falciforme, o que pode reduzir a frequência de crises dolorosas. Hidroxiureia é tipicamente administrado por via oral e pode ter efeitos colaterais, incluindo mielossupressão, distúrbios gastrointestinais e potenciais efeitos teratogênicos, exigindo monitoramento cuidadoso durante o tratamento. Seu mecanismo de ação e aplicações terapêuticas o tornam um agente significativo em oncologia e hematologia.
Fórmula:CH4N2O2
InChI:InChI=1S/CH4N2O2/c2-1(4)3-5/h5H,(H3,2,3,4)
Chave InChI:InChIKey=VSNHCAURESNICA-UHFFFAOYSA-N
SMILES:C(NO)(N)=O
Sinónimos:- 1-Hydroxyurea
- Amino(Oxido-Λ5-Azanyl)Methanone
- Biosupressin
- Carbamohydroxamic acid
- Carbamohydroximic acid
- Carbamoyl oxime
- Carbamyl hydroxamate
- Cytodrox
- Droxia
- HU
- Hidrix
- Ver mais sinónimos
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18 produtos.
Hydroxycarbamide CRS
CAS:Hydroxycarbamide CRSFórmula:CH4N2O2Cor e Forma:Crystalline Powder. White. Powder.Peso molecular:76.0547Hydroxyurea
CAS:Fórmula:CH4N2O2Pureza:98.0 - 102.0 % (anhydrous basis)Cor e Forma:White to off-white powderPeso molecular:76.06Hydroxyurea
CAS:Hydroxyurea (Hydroxycarbamide), an antineoplastic agent, inhibits DNA synthesis through the inhibition of ribonucleoside diphosphate reductase.Fórmula:CH4N2O2Pureza:99.85% - 99.92%Cor e Forma:SolidPeso molecular:76.05Hydroxycarbamide
CAS:HydroxycarbamideFórmula:CH4N2O2Pureza:99.6%Cor e Forma:Off-WhitePeso molecular:76.02728Hydroxyurea, 98%
CAS:This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.Fórmula:CH4N2O2Pureza:98%Cor e Forma:Crystalline powder, White to almost whitePeso molecular:76.06Hydroxy Urea
CAS:Produto ControladoStability Hygroscopic Applications An anti-neoplastic - inhibits ribonucleoside reductase and DNA replication. A potential therapy for sickle cell anemia which involves the nitrosylation of sickle cell hemoglobin. Horseradish peroxidase catalyzes nitric oxide formation from hydroxyurea in the presence of hydrogen peroxide. References Ratcliffe, W., et al.: Lancet, 339, 164 (1992), Roodman, G., et al.: Cancer, 80, 1557 (1997), Horwitz, M., et al.: J. Clin. Endocrinol. Metab., 2003, 88, 1603 (2003),Fórmula:CH4N2O2Cor e Forma:White SolidPeso molecular:76.05Hydroxyurea
CAS:HydroxyureaFórmula:CH4N2O2Pureza:98%Cor e Forma: white solidPeso molecular:76.05g/molHydroxyurea
CAS:Hydroxyurea is a prodrug that is activated by the enzyme Jak2, which is found in the mitochondria of cells. Hydroxyurea is used to treat various types of cancer and other diseases, such as sickle cell anemia. It has been shown to be effective in inhibiting the growth of squamous cell carcinomas and myeloid leukemia cells. Hydroxyurea has also been shown to have synergistic effects when combined with other pharmacological agents, such as hydroxycarbamide and cytosine arabinoside. Hydroxyurea inhibits the production of energy in the form of ATP, which leads to death by apoptosis or necrosis. This drug also has inhibitory properties against bacterial infections, especially those caused by Mycobacterium tuberculosis and Mycobacterium avium complex.Fórmula:CH4N2O2Pureza:Min. 97.5 Area-%Cor e Forma:White Off-White PowderPeso molecular:76.06 g/molHydroxyurea
CAS:Fórmula:CH4N2O2Pureza:>97.0%(HPLC)(N)Cor e Forma:White to Almost white powder to crystalPeso molecular:76.06Hydroxyurea, 98%
CAS:Hydroxyurea is used as an inhibitor of DNA synthesis and an anti-cancer drug. It is used as a precursor to prepare 1-hydroxy-5,6-dimethyl-1H-pyrimidine-2,4-dione via reaction with 2-methyl-3-oxo-butyric acid ethyl ester. It is used in the treatment of melanoma, resistant chronic myelocytic leukemia and recurrent metastatic or inoperable ovarian. It is also involved in reducing the rate of painful attacks in sickle-cell disease and has anti-retroviral properties in diseases such as AIDS. This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.Fórmula:CH4N2O2Pureza:98%Cor e Forma:White to cream or yellow, Crystals or powder or crystalline powderPeso molecular:76.06Hydroxyurea
CAS:Pureza:98.00%Cor e Forma:Solid, White crystalline powderPeso molecular:76.05500030517578Hydroxyurea
CAS:Non-aromatic organic derivatives of hydrazine or of hydroxylamine for use as drugsFórmula:CH4N2O2Cor e Forma:White Off-White PowderPeso molecular:76.06 g/mol
