CAS 474-25-9: Ácido quenodesoxicólico
Descrição:
Ácido quenodesoxicólico (CDCA) é um ácido biliar que desempenha um papel crucial na digestão e absorção de gorduras dietéticas e vitaminas lipossolúveis no intestino. É um pó cristalino branco a off-white que é solúvel em água e em solventes orgânicos como etanol e metanol. O CDCA é sintetizado no fígado a partir do colesterol e é um ácido biliar primário, o que significa que é produzido diretamente do colesterol em vez de ser derivado de outros ácidos biliares. Sua estrutura química apresenta um núcleo esteroide com grupos hidroxila em posições específicas, contribuindo para sua natureza anfipática, que permite emulsionar gorduras. O CDCA está envolvido na regulação do metabolismo do colesterol e tem sido estudado por seu potencial terapêutico em condições como cálculos biliares e certas doenças hepáticas. Além disso, pode influenciar o microbioma intestinal e tem implicações na saúde metabólica. Como substância de ocorrência natural, também é utilizado em várias formulações farmacêuticas e suplementos dietéticos.
Fórmula:C24H40O4
InChI:InChI=1S/C24H40O4/c1-14(4-7-21(27)28)17-5-6-18-22-19(9-11-24(17,18)3)23(2)10-8-16(25)12-15(23)13-20(22)26/h14-20,22,25-26H,4-13H2,1-3H3,(H,27,28)/t14-,15+,16-,17-,18+,19+,20-,22+,23+,24-/m1/s1
Chave InChI:InChIKey=RUDATBOHQWOJDD-BSWAIDMHSA-N
SMILES:C[C@@]12[C@]([C@]3([C@@]([C@]4(C)[C@](C[C@H]3O)(C[C@H](O)CC4)[H])(CC1)[H])[H])(CC[C@@]2([C@@H](CCC(O)=O)C)[H])[H]
Sinónimos:- (3Alpha,5Beta,7Alpha,8Xi,9Xi,14Xi)-3,7-Dihydroxycholan-24-Oic Acid
- (3Alpha,5Beta,7Alpha,8Xi,9Xi,14Xi)-3,7-Dihydroxycholan-24-Oicacid
- (3α,5β,7α)-3,7 Dihydroxycholan-24-oic acid
- (5Beta)-3,7-Dihydroxycholan-24-Oic Acid
- (5Beta)-3,7-Dihydroxycholan-24-Oicacid
- 17β-(1-Methyl-3-carboxypropyl)etiocholane-3α,7α-diol
- 3-Alpha,7-Alpha-Dihydroxy-5-Beta-Cholan-24-Oicacid
- 3alpha,7alpha-Dihydroxy-5beta-cholanic acid
- 3α,7α-Dihydroxy-5β-cholan-24-oic acid
- 3α,7α-Dihydroxy-5β-cholanic acid
- 3α,7α-Dihydroxy-5β-cholanoic acid
- Ver mais sinónimos
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Chenodeoxycholic acid for system suitability CRS
CAS:Chenodeoxycholic acid for system suitability CRSChenodeoxycholic acid for peak identification CRS
CAS:Chenodeoxycholic acid for peak identification CRSChenodeoxycholic acid
CAS:Fórmula:C24H40O4Pureza:≥ 98.0%Cor e Forma:White to off-white powderPeso molecular:392.57Chenodeoxycholic acid, 97%, from chicken
CAS:Fórmula:C24H40O4Pureza:≥ 97.0%Cor e Forma:White or off-white powderPeso molecular:392.57Chenodeoxycholic Acid
CAS:Produto ControladoImpurity Ursodeoxycholic Acid EP Impurity A Applications Chenodeoxycholic Acid (Ursodeoxycholic Acid EP Impurity A) is a major bile acid in many vertebrates, occurring as the N-glycine and/or N-taurine conjugate. With other bile acids, forms mixed micelles with lecithin in bile which solubilize cholesterol and thus facilitates its excretion. Facilitates fat absorption in the small intestine by micellar solubilization of fatty acids and monoglycerides. Anticholelithogenic. Epimeric with Ursodiol. References Danzinger, et al.: N. Engl. J. Med., 286, 1 (1972), Iser, J.H., et al.: Drugs, 21, 90 (1981), Tint, G.S., et al.: Gastroenterology, 91, 1007 (1986),Fórmula:C24H40O4Cor e Forma:BeigePeso molecular:392.57Chenodeoxycholic acid
CAS:Produto ControladoChenodeoxycholic acid is a human primary bile acid which is also found the bile of geese. Its C-7 epimer, Ursodeoxycholic acid is found in bearâs bile. Both bile acids are used for the treatment of gallstones, although Ursodeoxycholic acid has shown superior efficacy (bearâs bile extracts are also used in Chinese medicine).Fórmula:C24H40O4Pureza:Min. 95 Area-%Cor e Forma:White PowderPeso molecular:392.57 g/molChenodeoxycholic Acid (Ursodeoxycholic Acid EP Impurity A)
CAS:Fórmula:C24H40O4Cor e Forma:White To Off-White SolidPeso molecular:392.58Chenodeoxycholic acid
CAS:Chenodeoxycholic acidFórmula:C24H40O4Pureza:Loss on drying: 0.3%. (Typical Value in Batch COA)Cor e Forma: off-white powderPeso molecular:392.57g/molChenodeoxycholic Acid
CAS:Fórmula:C24H40O4Pureza:>97.0%(GC)Cor e Forma:White to Light yellow powder to crystalinePeso molecular:392.58Chenodeoxycholic acid
CAS:Chenodeoxycholic acid (CDCA), a bile acid, usually conjugated with either glycine or taurine, acts as a detergent to solubilize fats for intestinal absorption.Fórmula:C24H40O4Pureza:99.70% - 99.72%Cor e Forma:White - Almost White Solid PowderPeso molecular:392.57Chenodeoxycholic acid
CAS:Pureza:95.0%Cor e Forma:Solid, Crystalline Powder or Needles or PowderPeso molecular:392.5799865722656(3α,5β,7α)-3,7-Dihydroxycholan-24-oic acid
CAS:Fórmula:C24H40O4Pureza:%Cor e Forma:SolidPeso molecular:392.572Ref: IN-DA0039AV
5g21,00€10g26,00€1kg521,00€25g36,00€3kg911,00€50g52,00€100g82,00€250g149,00€500g202,00€Chenodeoxycholic Acid-d7 (Major)
CAS:Produto ControladoApplications Chenodeoxycholic Acid-d7 is a labelled analogue of Chenodeoxycholic Acid (C291900), which is a major bile acid in many vertebrates, occurring as the N-glycine and/or N-taurine conjugate. With other bile acids, forms mixed micelles with lecithin in bile which solubilize cholesterol and thus facilitates its excretion. Fcilitates fat absorption in the small intestine by micellar solubilization of fatty acids and monoglycerides. Anticholelithogenic. Epimeric with Ursodiol. In addition, Chenodeoxycholic Acid-d7 is an intermediate in synthesizing Glycochenodeoxycholic Acid-d7 Sodium Salt (G641257), which is a labelled Glycochenodeoxycholic Acid (G641255). A bile salt formed in the liver from chenodeoxycholate and glycine, usually as the sodium salt. It acts as a detergent to solubilize fats for References Danzinger, et al.: N. Engl. J. Med., 286, 1 (1972); Iser, J.H., et al.: Drugs, 21, 90 (1981); Tint, G.S., et al.: Gastroenterology, 91, 1007 (1986); Ollila, F., et al.: Langmuir, 17, 7107 (2001); Uekama, K., et al.: Chem. Pharm. Bull., 52, 900 (2004); Tongiani, S., et al.: J. Pharm. Sci., 94, 2380 (2005)Fórmula:C24H33D7O4Cor e Forma:NeatPeso molecular:399.62Chenodeoxycholic acid
CAS:Produto ControladoChenodeoxycholic acid is a human primary bile acid which is also found the bile of geese. Its C-7 epimer, Ursodeoxycholic acid is found in bears bile. Both bile acids are used for the treatment of gallstones, although Ursodeoxycholic acid has shown superior efficacy (bears bile extracts are also used in Chinese medicine).Fórmula:C24H40O4Pureza:Min. 98 Area-%Peso molecular:392.58 g/mol
