CAS 50-63-5: (±)-Dihidrogenofosfato de cloroquina
Descrição:
(±)-Dihidrogenofosfato de cloroquina é um composto sintético conhecido principalmente por seu uso como agente antimalárico. Pertence à classe das 4-aminoquinolinas e é caracterizado por sua capacidade de interferir no crescimento do parasita da malária, inibindo a polimerização de heme, que é crucial para a sobrevivência do parasita. O composto exibe uma natureza quiral, com dois enantiômeros, que podem influenciar sua atividade farmacológica e efeitos colaterais. Além de suas propriedades antimaláricas, a cloroquina tem sido investigada por seus potenciais efeitos antivirais e como agente imunomodulador em várias doenças autoimunes. A forma de sal de difosfato melhora sua solubilidade e estabilidade em soluções aquosas, tornando-a adequada para formulações farmacêuticas. A cloroquina é tipicamente administrada por via oral e tem uma meia-vida relativamente longa, permitindo a dosagem uma vez ao dia em alguns casos. No entanto, seu uso tem sido associado a efeitos colaterais, incluindo distúrbios gastrointestinais e potencial toxicidade retiniana com o uso a longo prazo. Assim como com qualquer medicamento, a consideração cuidadosa de seus benefícios e riscos é essencial em ambientes clínicos.
Fórmula:C18H26ClN3·2H3O4P
InChI:InChI=1S/C18H26ClN3.H3O4P/c1-4-22(5-2)12-6-7-14(3)21-17-10-11-20-18-13-15(19)8-9-16(17)18;1-5(2,3)4/h8-11,13-14H,4-7,12H2,1-3H3,(H,20,21);(H3,1,2,3,4)
Chave InChI:InChIKey=AEUAEICGCMSYCQ-UHFFFAOYSA-N
SMILES:P(=O)(O)(O)O.N(C(CCCN(CC)CC)C)C=1C2=C(N=CC1)C=C(Cl)C=C2
Sinónimos:- 1,4-Pentanediamine, N<sup>4</sup>-(7-chloro-4-quinolinyl)-N<sup>1</sup>,N<sup>1</sup>-diethyl-, phosphate (1:2)
- 3377 Rp
- 3377Rp
- 7-Chlor-4-(4-diaethylamino)-1-methylbutylamino)-chinolindiphosphat
- 7-Chloro-4-((4-(diethylamino)-1-methylbutyl)amino)quinoline phosphate (1:2)
- 7-Chloro-4-[(4′-diethylamino-1-methylbutyl)amino]quinoline diphosphate
- Ai3-14952
- Alermine
- Alexoquine
- Aralen diphosphate
- Aralen phosphate
- Ver mais sinónimos
Ordenar por
Chloroquine phosphate for peak identification CRS
CAS:Chloroquine phosphate for peak identification CRSChloroquine diphosphate salt, 98%
CAS:This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.Fórmula:C18H32ClN3O8P2Pureza:98%Cor e Forma:White to beige, PowderPeso molecular:515.86Chloroquine diphosphate salt
CAS:Fórmula:C18H26ClN3·2H3PO4Pureza:(Titration) 98.0 - 102.0 % (dried basis)Cor e Forma:White or almost white crystalline powderPeso molecular:515.87Quinoline, 7-chloro-4-[(4-diethylamino-1-methylbutyl)amino]-, diphosphate (6CI)
CAS:Fórmula:C18H30ClN3O7P2Pureza:98%Cor e Forma:SolidPeso molecular:497.8472Chloroquine phosphate
CAS:Chloroquine phosphate (Aralen phosphate) is an aminoquinoline antimalarial and also is used as an autophagy inhibitor. Chloroquine also is an inhibitor of TLRs.Fórmula:C18H26CLN3·2(H3PO4)Pureza:99.64% - ≥95%Cor e Forma:White To Slightly Yellow Crystalline Powder White SolidPeso molecular:515.87Chloroquine phosphate
CAS:Chloroquine phosphateFórmula:C18H26ClN3H3PO4Pureza:98.4%Cor e Forma:Light BrownPeso molecular:417.15842Chloroquine-d5 Diphosphate
CAS:Fórmula:C18H21D5ClN3·2H3O4PCor e Forma:White To Off-White SolidPeso molecular:324.91 2*97.99Chloroquine Diphosphate
CAS:Fórmula:C18H26ClN3·2H3O4PCor e Forma:White To Off-White SolidPeso molecular:319.88 2*97.99Chloroquine Phosphate
CAS:Drugs containing a quinoline or isoquinoline ring-system (whether or not hydrogenated) not further fusedFórmula:C18H26ClN3·2H3PO4Cor e Forma:Yellow PowderPeso molecular:515.13532Chloroquine-d4 Phosphate Salt
CAS:Produto ControladoApplications Labelled anti-malarial drug. Substrate for MRP in multidrug resistant cell line and inhibits photoaffinity labelling of MRP by quinoline-based photoactive drug IAAQ. It is a COVID19-related research product. References Luthman, H., et al.: Nucleic Acids Res., 11, 1295 (1983), Vezmar, M., et al.: Biochem. Pharmacol., 56, 733 (1998), Krajewski, W.A., et al.: J. Biomol. Struct. Dyn., 16, 1097 (1999),Fórmula:C18H22D4ClN3•xH3PO4Cor e Forma:Yellow SolidPeso molecular:323.9098Chloroquine diphosphate
CAS:Produto ControladoChloroquine is a 4-aminoquinolone that is used to prevent and treat malaria, caused by parasitic protozoan from the Plasmodium genus. Chloroquine i a schizonticidal agent and is a widely prescribed antimalarial compound. The antiviral activity of chloroquine in vitro has been reported in 1960’s and recent publications have brought attention to its possible benefits in the treatment of COVID-19 patients, infected with the newly emerged coronavirus (SARS-CoV-2). Current evidence shows that chloroquine inhibits SARS CoV-2 entry in host cells by interfering with endocytosis and affecting the glycoprofile on the S-glycoprotein.Fórmula:C18H32ClN3O8P2Cor e Forma:White Off-White PowderPeso molecular:515.86 g/molChloroquine diphosphate salt, 98%
CAS:Chloroquine diphosphate salt is used to study the role of endosomal acidification in cellular processes, such as the signaling of intracellular TLRs. It can be used as DNA intercalator & to dissociate antigen antibody complexes without denaturing red blood cell antigens. Chloroquine showed very high antiviral activity against NiV but very little activity against the other viruses at concentrations lower than 20 μM.This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.Fórmula:C18H32ClN3O8P2Pureza:98%Cor e Forma:Powder or crystals or crystalline powder, White to off-whitePeso molecular:515.86Chloroquine Diphosphate Salt
CAS:Stability Hygroscopic Applications Standard anti-malarial drug. Substrate for MRP in multidrug resistant cell line and inhibits photoaffinity labelling of MRP by quinoline-based photoactive drug IAAQ. It is a COVID19-related research product. References Luthman, H., et al.: Nucleic Acids Res., 11, 1295 (1983), Vezmar, M., et al.: Biochem. Pharmacol., 56, 733 (1998), Krajewski, W.A., et al.: J. Biomol. Struct. Dyn., 16, 1097 (1999),Fórmula:C18H26ClN3·2H3O4PCor e Forma:Light BrownPeso molecular:515.86
![Quinoline, 7-chloro-4-[(4-diethylamino-1-methylbutyl)amino]-, diphosphate (6CI)](/_next/image/?url=https%3A%2Fstatic.cymitquimica.com%2Fproducts%2FIN%2Fthumb%2FDA0034LP.jpg&w=3840&q=75)
