CAS 52665-69-7: Calcimicina
Descrição:
Calcimicina, também conhecido como A23187, é um antibiótico ionóforo polietérico que é derivado principalmente da fermentação da bactéria *Streptomyces chartreusis*. É caracterizado por sua capacidade de transportar íons de cálcio através de membranas biológicas, o que pode influenciar significativamente os processos celulares. Calcimicina exibe uma alta afinidade por cátions divalentes, particularmente cálcio, e também pode se ligar a outros íons metálicos, como magnésio e bário. O mecanismo de ação deste ionóforo envolve a formação de um complexo com íons de cálcio, facilitando sua passagem através de membranas lipídicas, o que pode levar a alterações na sinalização celular e na homeostase. Em ambientes de pesquisa e clínicos, Calcimicina tem sido estudado por suas potenciais aplicações em vários campos, incluindo terapia do câncer e imunologia, devido à sua capacidade de modular processos dependentes de cálcio. No entanto, seu uso é frequentemente limitado por sua toxicidade e o potencial de efeitos adversos. No geral, Calcimicina é um composto significativo no estudo do transporte iônico e da regulação celular.
Fórmula:C29H37N3O6
InChI:InChI=1S/C29H37N3O6/c1-15-10-11-29(17(3)13-16(2)27(38-29)18(4)26(33)20-7-6-12-31-20)37-22(15)14-23-32-25-21(36-23)9-8-19(30-5)24(25)28(34)35/h6-9,12,15-18,22,27,30-31H,10-11,13-14H2,1-5H3,(H,34,35)/t15-,16-,17-,18-,22-,27+,29+/m1/s1
Chave InChI:InChIKey=HIYAVKIYRIFSCZ-CYEMHPAKSA-N
SMILES:C[C@H]1[C@]2(O[C@]([C@@H](C(=O)C3=CC=CN3)C)([C@H](C)C1)[H])O[C@H](CC4=NC=5C(O4)=CC=C(NC)C5C(O)=O)[C@H](C)CC2
Sinónimos:- 1,7-Dioxaspiro[5.5]undecane, 4-benzoxazolecarboxylic acid deriv.
- 4-Benzoxazolcarbonsaure, 5-(Methylamino)-2-[[3,9,11-trimethyl-8-[1-methyl-2-oxo-2-(1H-pyrrol-2-yl)ethyl]-1,7-dioxaspiro[5.5]undec-2-yl]methyl]-, [6S-[6α(2S*,3S*),8β(R*),9β,11α]]-
- 4-Benzoxazolecarboxylic acid, 5-(methylamino)-2-[[(2R,3R,6S,8S,9R,11R)-3,9,11-trimethyl-8-[(1S)-1-methyl-2-oxo-2-(1H-pyrrol-2-yl)ethyl]-1,7-dioxaspiro[5.5]undec-2-yl]methyl]-
- 4-Benzoxazolecarboxylic acid, 5-(methylamino)-2-[[(2R,3R,8S,9R,11R)-3,9,11-trimethyl-8-[(1S)-1-methyl-2-oxo-2-(1H-pyrrol-2-yl)ethyl]-1,7-dioxaspiro[5.5]undec-2-yl]methyl]-
- 5-(Methylamino)-2-[[(2R,3R,6S,8S,9R,11R)-3,9,11-trimethyl-8-[(1S)-1-methyl-2-oxo-2-(1H-pyrrol-2-yl)ethyl]-1,7-dioxaspiro[5.5]undec-2-yl]methyl]-4-benzoxazolecarboxylic acid
- A 23187
- Antibiotic A 23187
- Calcimycin
- Calcium ionophore A 23187
- Calcium ionophore III
- Calimycin
- Ver mais sinónimos
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8 produtos.
Antibiotic A23187, 98%
CAS:A23187 (Mixed Calcium-Magnesium Salt) is used in cell activation experiments when calcium dose-response data are not required. Ca-Mg ratio ∼ 1:1. it is widely used as a compound in cell activation. It is used as a highly selective Ca2+ ionophore. it is used in studies of intracellular Ca2+ mediated events. A23187 has been observed to induce cell activation, differentiation or proliferation. In vitro experimentation has shown A23187 to boost ROS generation and platelet fragmentation. A23187 is a widely used ionophore. It has the ability to increase the intracellular concentrations of cations and is widely used to increase the intracellular levels of calcium. Visualization of Synaptic Ca2+ Calmodulin-Dependent Protein Kinase II Activity in Living Neurons. This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.Fórmula:C29H37N3O6Pureza:98%Peso molecular:523.62A23187, 98%, free acid
CAS:This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.Fórmula:C29H37N3O6Pureza:98%Cor e Forma:White to off-white, SolidPeso molecular:523.63Calcimycin A23187
CAS:Calcimycin A23187Fórmula:C29H37N3O6Pureza:By hplc: 98.90% (Typical Value in Batch COA)Cor e Forma: white powderPeso molecular:523.62g/molCalcium Ionophore A23187
CAS:Calcium ionophore A23187 is an ionophore that binds to calcium ions, which then disrupts the membrane and inhibits cell function. Calcium ionophore A23187 has been shown to be effective in inducing apoptosis in human polymorphonuclear leukocytes and also as a model system for studying the apoptosis pathway. This drug has inhibitory properties against a wide range of natural compounds and pluripotent cells.Fórmula:C29H37N3O6Pureza:Min. 98 Area-%Cor e Forma:PowderPeso molecular:523.62 g/molRef: 3D-FC137477
Produto descontinuadoA23187
CAS:Produto ControladoApplications A23187 is calcium channel modulator; Highly selective Ca2+ ionophore. References Khin, P. P., et al.: Pharmacol., 99, 216-225 (2017); Han, N., et al.: Chin. Exp. Pharmacol. Physiol., 44, 257-265 (2017)Fórmula:C29H37N3O6Cor e Forma:NeatPeso molecular:523.62Calcimycin
CAS:Calcimycin (A-23187) is a polyether antibiotic that transports Ca²⁺, uncouples phosphorylation, and inhibits ATPase in mitochondria.Fórmula:C29H37N3O6Pureza:98%Cor e Forma:SolidPeso molecular:523.62Calcium Ionophore A23187
CAS:Fórmula:C29H37N3O6Pureza:≥ 98%Cor e Forma:White powderPeso molecular:523.62
