Bcr-Abl
Os inibidores de Bcr-Abl são terapias direcionadas que inibem a proteína de fusão Bcr-Abl, que é formada devido à translocação do cromossomo Filadélfia e é um dos principais fatores da leucemia mieloide crônica (LMC). Essa proteína também influencia a angiogênese, contribuindo para a progressão do tumor. Os inibidores de Bcr-Abl são essenciais no tratamento da LMC e estão sendo explorados por seu potencial em inibir a angiogênese em vários tipos de câncer. Na CymitQuimica, oferecemos inibidores de Bcr-Abl de alta qualidade para apoiar sua pesquisa em biologia do câncer, angiogênese e terapias direcionadas.
Produtos da "Bcr-Abl"
Ordenar por
Degrasyn
CAS:Degrasyn (WP1130) inhibits DUBs (USP5, UCH-L1, USP9x, USP14, UCH37) and Bcr/Abl without affecting the 20S proteasome.Fórmula:C19H18BrN3OPureza:98.32% - 99.98%Cor e Forma:SolidPeso molecular:384.27Ref: TM-T6300
2mg44,00€5mg64,00€10mg97,00€25mg198,00€50mg340,00€100mg532,00€200mg747,00€1mL*10mM (DMSO)69,00€Imatinib
CAS:Imatinib (STI571) is a multi-targeted receptor tyrosine kinase inhibitor that selectively inhibits the kinase activities of BCR/ABL, v-Abl, PDGFR, and c-kitFórmula:C29H31N7OPureza:100% - 99.94%Cor e Forma:Off White PowderPeso molecular:493.6Nilotinib hydrochloride
CAS:Nilotinib HCl (AMN-107 HCl), an oral Bcr-Abl inhibitor, targets neuroinflammation, cognitive issues, and chronic myelogenous leukemia.Fórmula:C28H23ClF3N7OPureza:100%Cor e Forma:SolidPeso molecular:565.98PPY A
CAS:PPY A is a potent inhibitor of T315l mutant and wild-type Abl kinase and inhibits the growth of Bcr-Abl T315l mutant or wild-type Bcr-Abl gene-transformed cellsFórmula:C22H20N4O2Pureza:98.77%Cor e Forma:SolidPeso molecular:372.42cSRC/BCR-ABL-IN-1
cSRC/BCR-ABL-IN-1 (compound 21b) is a potent inhibitor of Bcr-Abl and C-Src, with IC50 values of 56.2 nM and 101 nM, respectively. It exhibits cytotoxicity.Fórmula:C29H31Cl2N5O4Peso molecular:584.494Flumatinib
CAS:Flumatinib (HHGV678) is an orally bioavailable tyrosine kinase inhibitor flumatinib, with potential antineoplastic activity.Fórmula:C29H29F3N8OPureza:99.52% - 99.95%Cor e Forma:SolidPeso molecular:562.59Ref: TM-T4320
1mg35,00€5mg66,00€10mg87,00€25mg127,00€50mg163,00€100mg273,00€200mg409,00€500mg677,00€1mL*10mM (DMSO)87,00€Dasatinib monohydrate
CAS:Dasatinib monohydrate, an oral SRC-kinase inhibitor, counters imatinib-resistant chronic myeloid leukemia.Fórmula:C22H28ClN7O3SPureza:100% - 99.68%Cor e Forma:SolidPeso molecular:506.03c-ABL-IN-5
C-ABL-IN-5, a selective c-Abl inhibitor, exhibits neuroprotective properties and has favorable characteristics including blood-brain barrier permeability,Fórmula:C19H17F2N3OPureza:98%Cor e Forma:SolidPeso molecular:341.35Lyn-IN-1
CAS:Lyn-IN-1 (Bafetinib analog) is a selective and potent dual inhibitor of Bcr-Abl and LynFórmula:C30H31F3N8OPureza:97% - 99.33%Cor e Forma:SolidPeso molecular:576.62Ref: TM-T11916
1mg47,00€2mg56,00€5mg84,00€10mg124,00€25mg250,00€50mg393,00€100mg560,00€200mg815,00€1mL*10mM (DMSO)97,00€Dasatinib N-oxide
CAS:Dasatinib N-oxide is a key metabolite and potential impurity of the kinase inhibitor dasatinib.Fórmula:C22H26ClN7O3SPureza:98.54% - 99.85%Cor e Forma:SolidPeso molecular:504FGFRs-IN-1
FGFRs-IN-1 (Compound A16) is an orally active inhibitor targeting FGFR1/2/3/4, with IC50 values of 2.3, 7, 11, and 163 nM respectively. It also inhibits VEGFR1/2/3, Abl, and Flt3, with IC50 values of 61, 176, 112, 26, and 353 nM. The compound shows weak inhibition of CYP enzymes. FGFRs-IN-1 reduces the expression of α-SMA and collagen I, and it inhibits epithelial-mesenchymal transition (EMT) in A549 cells stimulated by TGF-β1. Additionally, FGFRs-IN-1 demonstrates anti-inflammatory activity in mouse models of lung fibrosis induced by Bleomycin and liver fibrosis induced by CCl4.Fórmula:C28H26Cl2N4O3Cor e Forma:SolidPeso molecular:537.44Tyrosine kinase-IN-9
CAS:Tyrosine kinase-IN-9 (Compound B) is an inhibitor of c-Abl. It is useful for studying neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease.Fórmula:C20H14ClN3O3Cor e Forma:SolidPeso molecular:379.796AN-019
CAS:AN-019 (NRC-019) is a Bcr-Abl kinase inhibitor with antitumor activity for the study of chronic myelogenous leukemia (CML) and breast cancer.Fórmula:C25H17F6N5OPureza:98.01%Cor e Forma:SolidPeso molecular:517.43Flumatinib mesylate
CAS:Flumatinib mesylate (HHGV678 mesylate) is a selective inhibitor of c-Abl, PDGFRβ and c-Kit, effectively overcomes drug resistance of certain KIT mutants.Fórmula:C30H33F3N8O4SPureza:99.82%Cor e Forma:SolidPeso molecular:658.69Ref: TM-T7861
1mg37,00€5mg88,00€10mg133,00€25mg250,00€50mg393,00€100mg628,00€500mg1.301,00€1mL*10mM (DMSO)139,00€CZC-8004
CAS:CZC-8004 (CZC-00008004) is a pan-kinase(ABL kinase) inhibitor and binds a range of tyrosine kinases.Fórmula:C17H16FN5Pureza:99.29%Cor e Forma:SolidPeso molecular:309.34Rebastinib
CAS:DCC-2036 (Rebastinib (DCC-2036)) is a conformational control Bcr-Abl inhibitor for Abl1(WT, IC50: 0.8 nM) and Abl1(T315I, IC50: 4 nM), also inhibits LYN, SRC,Fórmula:C30H28FN7O3Pureza:99.53% - 99.79%Cor e Forma:SolidPeso molecular:553.59GMB-475
CAS:GMB-475, a PROTAC-based BCR-ABL1 inhibitor, tackles drug resistance by promoting VHL-mediated degradation.Fórmula:C43H46F3N7O7SPureza:100% - 98.78%Cor e Forma:SolidPeso molecular:861.93Ref: TM-T8488
1mg96,00€5mg200,00€10mg350,00€25mg590,00€50mg840,00€100mg1.130,00€500mg2.308,00€1mL*10mM (DMSO)274,00€CpCDPK1/TgCDPK1-IN-1
CAS:CpCDPK1/TgCDPK1-IN-1 is a inhibitor of CpCDPK1 and TgCDPK1, inhibits Abl and Src, and has antiparasitic activity for the study of Toxoplasma infections.Fórmula:C18H17N5Pureza:98.71%Cor e Forma:SolidPeso molecular:303.36Dasatinib
CAS:Dasatinib (BMS-354825) is a tyrosine kinase inhibitor that inhibits Src and Bcr-Abl (Ki=16/30 pM) and is orally active and ATP-competitive.Fórmula:C22H26ClN7O2SPureza:99.59% - 99.86%Cor e Forma:Pale-Yellow SolidPeso molecular:488.01PD173955
CAS:PD173955 is src family-selective tyrosine kinase inhibitor with IC50 of ~22 nM for Src, Yes and Abl kinase; less potent for FGFRα and no activity on InsR andFórmula:C21H16Cl2N4OSPureza:98.52% - 99.28%Cor e Forma:SolidPeso molecular:443.35
