EGFR
Os inibidores do receptor do fator de crescimento epidérmico (EGFR) são compostos que bloqueiam a sinalização do EGFR, um receptor frequentemente superexpresso em vários tipos de câncer e que desempenha um papel crucial na angiogênese. Os inibidores de EGFR são usados para prevenir o crescimento e a metástase de tumores, interrompendo as vias que promovem a formação de vasos sanguíneos nos tumores. Esses inibidores são amplamente utilizados na pesquisa e terapia do câncer. Na CymitQuimica, oferecemos uma seleção diversificada de inibidores de EGFR de alta qualidade para apoiar sua pesquisa em oncologia e angiogênese.
Produtos da "EGFR"
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Losatuxizumab
CAS:Losatuxizumab (ABT-806) is an anti-EGFR monoclonal antibody with potential anti-tumor activity for the study of advanced malignant solid tumors.Pureza:95% - 95%Cor e Forma:LiquidNaquotinib
CAS:Naquotinib (ASP8273) (ASP8273) is an orally available, mutant-selective and irreversible EGFR inhibitor; (IC50s: 8-33 nM and 230 nM toward EGFR mutants and EGFRFórmula:C30H42N8O3Pureza:97.49%Cor e Forma:SolidPeso molecular:562.71Nimotuzumab
CAS:Nimotuzumab is a humanized therapeutic monoclonal antibody against epidermal growth factor receptor EGFR).Pureza:95.00%Cor e Forma:LiquidWZ8040
CAS:WZ8040 is a novel mutant-selective irreversible EGFRT790M inhibitor, does not inhibit ERBB2 phosphorylation (T798I).Fórmula:C24H25ClN6OSPureza:97.42%Cor e Forma:SolidPeso molecular:481.01H-9 dihydrochloride
CAS:H-9 dihydrochloride: Strong PKA inhibitor, curbs 5-HT response and EGF signaling, affects pharyngeal function.Fórmula:C11H15Cl2N3O2SPureza:96.57%Cor e Forma:SolidPeso molecular:324.23CL-387785
CAS:Fórmula:C18H13BrN4OPureza:>98.0%(GC)Cor e Forma:White to Light yellow powder to crystalPeso molecular:381.23Erlotinib
CAS:Erlotinib (NSC-718781) is an EGFR inhibitor (IC50: 2 nM). It is used for the treatment of non-small cell lung cancer.Fórmula:C22H23N3O4Pureza:98.19% - 99.98%Cor e Forma:White To Off-White PowderPeso molecular:393.44Butein
CAS:Butein is a cAMP-specific PDE inhibitor, protein tyrosine kinase inhibitor, and SIRT1 activator.Cost-effective and quality-assured.Fórmula:C15H12O5Pureza:100% - 99.85%Cor e Forma:SolidPeso molecular:272.25Ref: TM-T6427
1mg43,00€2mg56,00€5mg88,00€10mg106,00€25mg213,00€50mg344,00€100mg550,00€1mL*10mM (DMSO)87,00€Genistein
CAS:Genistein (NPI 031L) is a natural soy isoflavone, a multi-targeted tyrosine kinase inhibitor. Genistein has antitumor effects. Cost effective and quality assured.Fórmula:C15H10O5Pureza:98.22% - 99.69%Cor e Forma:Rectangular Or Six-Sided Rods From 60% Alcohol Dendritic Needles From Ether SolidPeso molecular:270.24YK-029A
CAS:YK-029A, an orally active EGFR mutant inhibitor, targets both EGFR T790M and EGFRex20ins mutations.Fórmula:C27H32N8O2Pureza:98%Cor e Forma:SolidPeso molecular:500.6Antiproliferative agent-34
CAS:Antiproliferative Agent-34 (Compound A14), a multitarget kinase inhibitor, demonstrates IC50 values of 177 nM for EGFR L858R/T790M and 1567 nM for EGFR WT.Fórmula:C27H27N7O5Pureza:98%Cor e Forma:SolidPeso molecular:529.55PD153035
CAS:PD153035 (NSC-669364) hydrochloride is an effective and selective inhibitor of EGFR (Ki/IC50: 5.2/29 pM, in cell-free assays); little inhibitory against FGFR,Fórmula:C16H14BrN3O2Pureza:98.47% - 99.29%Cor e Forma:SolidPeso molecular:360.21Rostafuroxin
CAS:Rostafuroxin (PST 2238) has been used in trials studying the treatment of Essential Hypertension.Fórmula:C23H34O4Pureza:100% - 99.08%Cor e Forma:SolidPeso molecular:374.51EGFR/HER2/DHFR-IN-2
EGFR/HER2/DHFR-IN-2 (Compound 4b) serves as an inhibitor for EGFR, HER2, and DHFR, with IC50 values of 0.248, 0.156, and 0.138 μM, respectively.Pureza:98%Cor e Forma:Odour SolidCurcumin (Synthetic)
CAS:Fórmula:C21H20O6Pureza:>97.0%(T)Cor e Forma:Light yellow to Brown powder to crystalPeso molecular:368.39ES-072
CAS:ES-072, a selective inhibitor targeting the EGFR mutant (EGFR-T790M), is administered orally. By hindering EGFR-T790M activity, it activates GSK3α, which subsequently leads to the phosphorylation of PD-L1 at Ser279 and Ser283. This phosphorylation facilitates the recruitment of the E3 ubiquitin ligase ARIH1, resulting in the ubiquitination and proteasomal degradation of PD-L1. Such a process not only curtails the growth of cancer cells but also amplifies the anti-tumor immune response by diminishing PD-L1 levels. ES-072 has shown efficacy in impeding the proliferation of non-small cell lung cancer (NSCLC) cells.Fórmula:C25H27F3N8O2Cor e Forma:SolidPeso molecular:528.53Icotinib Hydrochloride
CAS:Icotinib Hydrochloride, an oral EGFR inhibitor (BPI-2009H), may halt cancer growth by blocking EGFR signaling.Fórmula:C22H22ClN3O4Pureza:99.77%Cor e Forma:SolidPeso molecular:427.88TAS6417
CAS:Zipalertinib (TAS6417, CLN-081) is a novel, highly potent, orally active covalent EGFR tyrosine kinase inhibitor.Cost-effective and quality-assured.Fórmula:C23H20N6OPureza:99.71%Cor e Forma:SolidPeso molecular:396.44Ref: TM-T16996
1mg87,00€2mg124,00€5mg188,00€10mg311,00€25mg630,00€50mg1.008,00€100mg1.549,00€500mg3.117,00€1mL*10mM (DMSO)215,00€ALK/EGFR-IN-1
CAS:ALK/EGFR-IN-1 (Compound 8l) is a dual inhibitor targeting both ALK and EGFR, effectively blocking their phosphorylation.Fórmula:C27H34ClN7O3SPureza:98%Cor e Forma:SolidPeso molecular:572.12(2E)-N-[4-[[3-Chloro-4-(2-pyridinylmethoxy)phenyl]amino]-3-cyano-7-ethoxy-6-quinolinyl]-4-(dimethylamino)-2-butenamide
CAS:Fórmula:C30H29ClN6O3Pureza:98%Cor e Forma:SolidPeso molecular:557.0426600000001
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