Mdm2
Os inibidores de Mdm2 têm como alvo a proteína Mdm2, uma ligase de ubiquitina E3 que regula negativamente o supressor tumoral p53. A Mdm2 promove a degradação de p53, impedindo assim a apoptose em células que deveriam passar por morte celular. Inibir a Mdm2 estabiliza p53, aumentando sua atividade supressora de tumores e promovendo a apoptose em células cancerígenas. Os inibidores de Mdm2 são cruciais na pesquisa e terapia do câncer, especialmente para cânceres com vias de p53 intactas. Na CymitQuimica, oferecemos inibidores de Mdm2 de alta qualidade para apoiar sua pesquisa em biologia do câncer, apoptose e desenvolvimento terapêutico.
Produtos da "Mdm2"
Ordenar por
34 produtos desta categoria.
Alrizomadlin
CAS:Alrizomadlin is an orally active MDM2 inhibitor. APG-115 shows significant dose-dependent inhibitory effects on TP53wt AML cell lines.Cost-effective and quality-assured.Fórmula:C34H38Cl2FN3O4Pureza:98.69% - 98.79%Cor e Forma:SolidPeso molecular:642.59Ref: TM-T14303
1mg52,00€5mg111,00€10mg180,00€25mg359,00€50mg588,00€100mg944,00€200mg1.264,00€1mL*10mM (DMSO)159,00€NVP-CGM097
CAS:NVP-CGM097 (CGM097) is an effective and specific MDM2 inhibitor (IC50: 1.7 nM for hMDM2).Fórmula:C38H47ClN4O4Pureza:98.77%Cor e Forma:SolidPeso molecular:659.26Ref: TM-TQ0231
1mg87,00€5mg207,00€10mg341,00€25mg520,00€50mg682,00€100mg944,00€1mL*10mM (DMSO)300,00€RO-5963
CAS:RO-5963 is a dual inhibitor of p53-MDM2 and p53-MDMX (IC50s: ~17 nM and ~24 nM, respectively).Fórmula:C24H21ClF2N4O5Pureza:98%Cor e Forma:SolidPeso molecular:518.9Ref: TM-T16771
1mg70,00€5mg197,00€10mg284,00€25mg434,00€50mg562,00€100mg780,00€200mg1.035,00€1mL*10mM (DMSO)224,00€Tenovin-6
CAS:Tenovin-6 is a p53 transcriptional activity agonist.Fórmula:C25H34N4O2SPureza:100% - 97.71%Cor e Forma:SolidPeso molecular:454.63Ref: TM-T1818
1mg43,00€2mg56,00€5mg77,00€10mg87,00€25mg157,00€50mg230,00€100mg393,00€500mg930,00€1mL*10mM (DMSO)79,00€MB710
CAS:MB710 is an amino-benzothiazole derivative that tightly binds to the Y220C pocket and stabilizes p53-Y220C in vitro.Fórmula:C16H16IN3O3SPureza:99.02%Cor e Forma:SolidPeso molecular:457.29Nutlin-3b
CAS:Nutlin-3b, a less potent (+)-enantiomer of Nutlin-3, inhibits p53/MDM2 at IC50: 13.6 μM, 150x weaker than Nutlin-3a.Fórmula:C30H30Cl2N4O4Pureza:98.83%Cor e Forma:SolidPeso molecular:581.49Ref: TM-T6614
1mg42,00€2mg55,00€5mg88,00€10mg137,00€25mg255,00€50mg424,00€100mg612,00€1mL*10mM (DMSO)97,00€PhiKan 083
CAS:PhiKan 083 is a carbazole derivativeFórmula:C16H18N2Pureza:98.37%Cor e Forma:SolidPeso molecular:238.33Ref: TM-T16523L
1mg35,00€5mg70,00€10mg111,00€25mg235,00€50mg329,00€100mg464,00€500mg1.008,00€1mL*10mM (DMSO)75,00€Tenovin-6 Hydrochloride
CAS:Tenovin-6 HCl: Inhibits SIRT1 (21µM), SIRT2 (10µM), HDAC8; potent p53 activator.Fórmula:C25H35ClN4O2SPureza:99.36%Cor e Forma:SolidPeso molecular:491.09Ref: TM-T8480
1mg39,00€2mg51,00€5mg70,00€10mg88,00€25mg140,00€50mg226,00€100mg376,00€1mL*10mM (DMSO)73,00€NSC 66811
CAS:NSC 66811 inhibits MDM2-p53 interaction with 120 nM affinity, activating p53 in cancer cells.Fórmula:C23H20N2OPureza:96.94%Cor e Forma:SolidPeso molecular:340.42RG7112
CAS:RG7112 (RO5045337) (RO5045337) is an orally bioavailable and selective p53-MDM2 inhibitor.Fórmula:C38H48Cl2N4O4SPureza:99.17% - 99.92%Cor e Forma:SolidPeso molecular:727.78Ref: TM-T6965
1mg48,00€2mg65,00€5mg96,00€10mg169,00€25mg325,00€50mg495,00€100mg718,00€500mg1.501,00€1mL*10mM (DMSO)155,00€Kevetrin hydrochloride
CAS:Kevetrin hydrochloride (4-Isothioureidobutyronitrile hydrochloride) is a small molecule and activator of the tumor suppressor protein p53, with potentialFórmula:C5H10ClN3SPureza:99.32% - 99.93%Cor e Forma:SolidPeso molecular:179.67MA242
CAS:MA242 is a nuclear factor of activated T cells 1 (NFAT1) for Pancreatic Cancer Therapy and dual inhibitor of murine double minute 2 (MDM2).Fórmula:C26H21ClF3N3O5SPureza:98%Cor e Forma:SolidPeso molecular:579.98UC2288
CAS:UC2288, a Sorafenib-based p21 attenuator, reduces p21 levels without affecting its stability.Fórmula:C20H18ClF6N3O2Pureza:99.75%Cor e Forma:SolidPeso molecular:481.82Ref: TM-T9698
1mg48,00€5mg96,00€10mg144,00€25mg263,00€50mg393,00€100mg487,00€200mg607,00€500mg882,00€1mL*10mM (DMSO)96,00€Navtemadlin
CAS:Navtemadlin (AMG232) is a potent, selective and orally available inhibitor of p53-MDM2 interaction (IC50: 0.6 nM).Cost-effective and quality-assured.Fórmula:C28H35Cl2NO5SPureza:95.55% - 98.86%Cor e Forma:SolidPeso molecular:568.55MI-1061
CAS:MI-1061 is a orally bioavailable inhibitor of MDM2 (MDM2-p53 interaction) (IC50=4.4 nM).Fórmula:C30H26Cl2FN3O4Cor e Forma:SolidPeso molecular:582.45AM-8735
CAS:AM-8735 is an inhibitor of MDM2 ( IC50: 25 nM).Fórmula:C27H31Cl2NO6SPureza:98%Cor e Forma:SolidPeso molecular:568.51Amifostine thiol
CAS:Amifostine thiol (WR-1065), an active Amifostine metabolite, is a radioprotective cytoprotectant that activates p53 via JNK pathway.Fórmula:C5H14N2SPureza:≥95.0%Cor e Forma:SolidPeso molecular:134.24Tenovin-1
CAS:Tenovin-1 inhibits protein-deacetylating activities of SirT1 and SirT2 and protects against MDM2-mediated p53 degradation, which involves ubiquitination.Fórmula:C20H23N3O2SPureza:99.33%Cor e Forma:SolidPeso molecular:369.48Idasanutlin
CAS:Idasanutlin (Ro 5503781) (RG-7388) is an effective and specific p53-MDM2 inhibitor (IC50: 6 nM).Fórmula:C31H29Cl2F2N3O4Pureza:98.85% - 99.86%Cor e Forma:SolidPeso molecular:616.48Ref: TM-T6254
2mg40,00€5mg60,00€10mg96,00€25mg159,00€50mg226,00€100mg376,00€500mg883,00€1mL*10mM (DMSO)84,00€RITA
CAS:RITA (NSC-652287) forms DNA-DNA/protein cross-links without DNA breaks; disrupts p53/Mdm2 like nutlin-3.Fórmula:C14H12O3S2Pureza:97.76% - 98.85%Cor e Forma:SolidPeso molecular:292.37Ref: TM-T1798
1mg35,00€2mg46,00€5mg66,00€10mg96,00€25mg188,00€50mg344,00€100mg509,00€200mg715,00€500mg1.093,00€1mL*10mM (DMSO)89,00€SAR405838
CAS:MI-773 (SAR405838 (MI 773)) is an orally available MDM2 antagonist with Ki of 0.88 nM. Phase 1.Fórmula:C29H34Cl2FN3O3Pureza:98.04%Cor e Forma:SolidPeso molecular:562.5Ref: TM-T6585
1mg49,00€2mg90,00€5mg133,00€10mg213,00€25mg419,00€50mg617,00€100mg879,00€500mg1.776,00€p53-MDM2-IN-1
CAS:p53-MDM2-IN-1 (Example 30), an inhibitor targeting the p53-MDM2/X protein interaction, exhibits a K i value of 23.35 µM.Fórmula:C23H20ClN3O3Pureza:98.3%Cor e Forma:SoildPeso molecular:421.88SJ-172550
CAS:SJ-172550 is a small molecule inhibitor of MDMX (EC50: 5 μM).Fórmula:C22H21ClN2O5Pureza:99.87%Cor e Forma:SolidPeso molecular:428.87Ref: TM-T16888
2mg44,00€5mg65,00€10mg96,00€25mg185,00€50mg354,00€100mg607,00€500mg1.264,00€1mL*10mM (DMSO)72,00€SP-141
CAS:SP 141 is a MDM2 inhibitor.SP-141 promotes MDM2 auto-ubiquitination and degradation, with anticancer activity.Fórmula:C22H16N2OPureza:98.01%Cor e Forma:SolidPeso molecular:324.38MG-277
MG-277 is a molecular glue compound transformed from PROTAC degradation agent, MG-277 potently inhibits tumor cell growth in a p53-independent manner.Fórmula:C41H42Cl2FN5O5Pureza:98%Cor e Forma:SolidPeso molecular:774.71PK11007
CAS:PK11007 is an anti-p53 drug.Fórmula:C15H11ClFN5O3S2Pureza:≥98%Cor e Forma:SolidPeso molecular:427.86p53-Mdm2 inhibitor 4
CAS:p53-Mdm2 inhibitor 4 inhibits the p53-MDM2 protein-protein interaction.Fórmula:C23H20FN3O3Pureza:99.63%Cor e Forma:SoildPeso molecular:405.42RO8994
CAS:RO8994: potent MDM2 spiroindolinone inhibitor, IC50: 20 nM (proliferation), 5 nM (binding).Fórmula:C31H31Cl2FN4O4Pureza:99.31% - 99.44%Cor e Forma:SolidPeso molecular:613.51Ref: TM-T3517
1mg40,00€2mg52,00€5mg87,00€10mg127,00€25mg230,00€50mg364,00€100mg540,00€1mL*10mM (DMSO)105,00€Milademetan
CAS:Milademetan (DS-3032), an MDM2 inhibitor, exhibits antitumor activity, induces G1 cell cycle arrest and apoptosis, and can be used to study solid tumors.Fórmula:C30H34Cl2FN5O4Pureza:100%Cor e Forma:SolidPeso molecular:618.53Ref: TM-T12040
1mg170,00€5mg518,00€10mg753,00€25mg1.035,00€50mg1.454,00€100mg1.882,00€1mL*10mM (DMSO)35,00€MX69
CAS:MX69 is the MDM2/XIAP inhibitor, blocking the MDM2 protein-XIAP RNA interaction, leading to MDM2 degradation.Fórmula:C27H26N2O4SPureza:97.27% - 99.57%Cor e Forma:SolidPeso molecular:474.57Ref: TM-T3653
1mg37,00€2mg52,00€5mg79,00€10mg119,00€25mg227,00€50mg368,00€100mg547,00€500mg1.198,00€1mL*10mM (DMSO)82,00€XI-006
CAS:NSC-207895 (XI-006) suppresses MDMX with IC50 of 2.5 μM, leading to enhanced p53 stabilization/activation and DNA damage, and regulates MDM2, an E3 ligase.Fórmula:C11H13N5O4Pureza:99.12%Cor e Forma:SolidPeso molecular:279.25Ref: TM-T6610
1mg56,00€2mg81,00€5mg119,00€10mg187,00€25mg432,00€50mg638,00€100mg908,00€500mg1.825,00€1mL*10mM (DMSO)114,00€MD-224
CAS:MD-224 is a highly potent and efficacious MDM2 degrader based on the proteolysistargeting chimera (PROTAC) concept,and as a new class of anticancer agent.Fórmula:C48H43Cl2FN6O6Pureza:100% - 99.07%Cor e Forma:SolidPeso molecular:889.8Ref: TM-T11980
1mg70,00€5mg153,00€10mg274,00€25mg467,00€50mg655,00€100mg932,00€200mg1.283,00€1mL*10mM (DMSO)166,00€Brigimadlin
CAS:Brigimadlin (BI 907828) is an orally active and highly potent antagonist of the E3 ubiquitin-protein ligase MDM2-p53 with antitumor activity.Fórmula:C31H25Cl2FN4O3Pureza:98.17%Cor e Forma:SolidPeso molecular:591.46CP-31398 dihydrochloride
CAS:CP-31398 dihydrochloride is a p53 stabilizer which stabilizes the active conformation of p53 and promotes p53 activity in cancer cell lines.Fórmula:C22H28Cl2N4OPureza:98.23%Cor e Forma:SolidPeso molecular:435.4Ref: TM-T21648
5mg49,00€10mg74,00€25mg134,00€50mg207,00€100mg339,00€200mg470,00€1mL*10mM (DMSO)58,00€
