BCL
Os inibidores de BCL são compostos que têm como alvo a família de proteínas BCL-2, que desempenham um papel fundamental na regulação da apoptose. A família BCL-2 inclui membros pró-apoptóticos e anti-apoptóticos que controlam a via mitocondrial da apoptose. Inibir proteínas BCL-2 anti-apoptóticas pode promover a morte celular em células cancerígenas, tornando os inibidores de BCL cruciais na pesquisa de terapias contra o câncer. Na CymitQuimica, oferecemos uma seleção abrangente de inibidores de BCL de alta qualidade para apoiar sua pesquisa em câncer, apoptose e biologia celular.
Produtos da "BCL"
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PROTAC Bcl2 degrader-1
CAS:PROTAC Bcl2 degrader-1 is a PROTAC, which potently and selectively induces the degradation of Mcl-1 (IC50: 11.81 μM) and Bcl-2 (IC50: 4.94 μM; DC50: 3.0 μM).Fórmula:C45H45BrN6O10SPureza:98%Cor e Forma:SolidPeso molecular:941.84S55746 hydrochloride
CAS:S55746 hydrochloride is a potent, orally active and selective inhibitor of BCL-2(Ki of 1.3 nM and a Kd of 3.9 nM),with antitumor activity with low toxicity.Fórmula:C43H43ClN4O6Pureza:98%Cor e Forma:SolidPeso molecular:747.28Tanshinone IIB
CAS:TSB reduces DNA damage, cytotoxicity, and apoptosis in rat neurons, balances Bax, bcl-2, caspase-3 proteins, and has potential for treating stroke.Fórmula:C19H18O4Pureza:98%Cor e Forma:SolidPeso molecular:310.349Crenulatin
CAS:Crenulatin has dual- direction effects on apoptosis of cerebral microvascular endothelial cells, inhibitive effect in 25 mg/L and stimulative effect in 100 mg/LFórmula:C11H20O6Pureza:98%Cor e Forma:SolidPeso molecular:248.275Obovatol
CAS:Obovatol has antioxidant, neuroprotective, antiinflammatory, antithrombotic and antitumour effects, it is a potent NF-κB inhibitors for Alzheimer's diseaseFórmula:C18H18O3Pureza:98%Cor e Forma:SolidPeso molecular:282.33Isolimonexic acid
CAS:Isolimonexic acid exhibits cytotoxicity on MCF-7 cell lines, it also inhibits Panc-28 cancer cell growth.Fórmula:C26H30O10Pureza:98%Cor e Forma:SolidPeso molecular:502.51Ferruginol
CAS:Ferruginol exhibits anti-cancer, anti-inflammatory, cardioprotective properties and can trigger NSCLC cell apoptosis.Fórmula:C20H30OPureza:98%Cor e Forma:SolidPeso molecular:286.459Metaproterenol
CAS:Metaproterenol also has anti-inflammatory activity. Metaproterenol is a direct-acting sympathomimetic and a β2-adrenergic receptor (β2AR) agonist (IC50: 68 nM).Fórmula:C11H17NO3Pureza:98%Cor e Forma:SolidPeso molecular:211.26Panaxynol
CAS:Panaxynol is the most potent antiplatelet agent in ginseng and its mechanism of action is chiefly due to the inhibition of thromboxane formation.Fórmula:C17H24OPureza:98%Cor e Forma:SolidPeso molecular:244.37Coronarin D
CAS:Coronarin D has antifungal properties, with 2 mg/mL MIC & 4 mg/mL MFC against C. albicans, inhibits NF-kappaB, and enhances antibiotic effects.Fórmula:C20H30O3Pureza:98%Cor e Forma:SolidPeso molecular:318.457Tapotoclax
CAS:Tapotoclax (AMG-176) is an orally active MCL1 inhibitor for the study of myeloid leukemia.Fórmula:C33H41ClN2O5SPureza:98.8%Cor e Forma:SolidPeso molecular:613.21Liriodenine
CAS:Liriodenine: Topoisomerase II inhibitor, antitumor, antibacterial, antifungal, prevents arrhythmias, and may block M3 receptors.Fórmula:C17H9NO3Pureza:98%Cor e Forma:SolidPeso molecular:275.26WEHI-9625
CAS:WEHI-9625 is a tricyclic sulfone small molecule apoptosis inhibitor (EC50: 69 nM).Fórmula:C34H27NO5S2Pureza:98%Cor e Forma:SolidPeso molecular:593.71(S)-Purvalanol B
CAS:(S)-Purvalanol B is the S enantiomer of Purvalanol B. Purvalanol B is an inhibitor of cyclin-dependent kinase(CDK) .Fórmula:C20H25ClN6O3Pureza:98%Cor e Forma:SolidPeso molecular:432.9Altholactone
CAS:Altholactone, a potential antimicrobial for ciprofloxacin-resistant S. aureus/E. faecalis, also induces cancer cell apoptosis.Fórmula:C13H12O4Pureza:98%Cor e Forma:SolidPeso molecular:232.23WEHI-539 hydrochloride
CAS:WEHI-539 hydrochloride is a selective Bcl-XL inhibitor with an IC50 of 1.1 nM.Fórmula:C31H30ClN5O3S2Pureza:98%Cor e Forma:SolidPeso molecular:620.18Serratenediol
CAS:Serratenediol inhibits EBV-EA stronger than oleanolic acid, boosts osteoblast growth, and suppresses HL-60 cells by modulating Bax/Bcl-xL.Fórmula:C30H50O2Pureza:98%Cor e Forma:SolidPeso molecular:442.72Myricanone
CAS:Myricanone exhibits antioxidant, anticancer, apoptosis-inducing, and anti-androgenic properties with enzyme inhibition.Fórmula:C21H24O5Pureza:98%Cor e Forma:SolidPeso molecular:356.41Pyridoclax
CAS:Pyridoclax is an inhibitor of potential Mcl-1.Fórmula:C29H22N4Pureza:98%Cor e Forma:SolidPeso molecular:426.51Mcl1-IN-11
CAS:Mcl1-IN-11 (Compound G) is a selective Mcl-1 inhibitor, less potent at Bcl-2, with Kis of 0.06 and 4.2 μM, respectively.Fórmula:C38H41N3O5S2Pureza:98%Cor e Forma:SolidPeso molecular:683.88
