Ciclo celular/Ponto de verificação
Os inibidores do ciclo celular/ponto de verificação são compostos que interrompem a progressão normal do ciclo celular, particularmente em pontos de verificação regulatórios chave. Esses inibidores são cruciais para estudar a divisão celular, entender a proliferação de células cancerígenas e desenvolver terapias anticâncer. Ao direcionar fases específicas do ciclo celular, esses inibidores podem induzir a parada do ciclo celular, levando à apoptose ou senescência em células de divisão rápida. Na CymitQuimica, oferecemos uma ampla gama de inibidores de alta qualidade do ciclo celular/ponto de verificação para apoiar sua pesquisa em biologia do câncer, biologia celular e desenvolvimento de medicamentos.
Subcategorias de "Ciclo celular/Ponto de verificação"
- Aurora Quinase
- CDK
- Ciclo celular/Parada
- Chk
- c-Myc
- Dinamina
- DYRK
- Ferroptose
- HSP
- Integrinas
- Cinesina
- KSP
- LIM Quinase
- Microtúbulo associado
- PKC
- PLK
- Rho
- ROCK
- Wee1
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Produtos da "Ciclo celular/Ponto de verificação"
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LY3143921 hydrate
CAS:LY3143921 ((S)-Example 2) hydrate is an orally active CDC7 kinase inhibitor with broad in vitro anticancer activity [1].Fórmula:C16H14FN5O2Pureza:98.43%Cor e Forma:SolidPeso molecular:327.31CDK2-IN-39
CAS:CDK2-IN-39 (compound 4) is a CDK2 inhibitor.Fórmula:C14H15N3O4SCor e Forma:SolidPeso molecular:321.352COH29
CAS:COH29 is an oral RNR-blocking thiazole that may reduce DNA synthesis and promote apoptosis, with potential cancer-treating properties.Fórmula:C22H16N2O5SPureza:97.04% - 98.92%Cor e Forma:SolidPeso molecular:420.44Ref: TM-T3157
1mg37,00€2mg52,00€5mg79,00€10mg119,00€25mg217,00€50mg354,00€100mg590,00€1mL*10mM (DMSO)87,00€5'-Azido-5'-deoxythymidine
CAS:5'-Azido-5'-deoxythymidine is a nucleoside analog with potential anti-tuberculosis activity and an inhibitor of TMPKmt in Mycobacterium tuberculosis.Fórmula:C10H13N5O4Pureza:99.85%Cor e Forma:SolidPeso molecular:267.24NSC23005 Sodium
CAS:NSC23005 sodium is a novel and effective p18 inhibitor (ED50=5.21 nM) in promoting Hematopoietic stem cells (HSCs) expansion in both murine and human models.Fórmula:C13H16NNaO4SPureza:99.64%Cor e Forma:SolidPeso molecular:305.32Ref: TM-T3589
1mg47,00€2mg59,00€5mg93,00€10mg115,00€25mg245,00€50mg437,00€100mg625,00€1mL*10mM (DMSO)93,00€CCT241533
CAS:CCT241533 is an effective and selective ATP competitive inhibitor of CHK2 (Ki: 1.16 nM; IC50: 3 nM).Fórmula:C23H27FN4O4Pureza:98%Cor e Forma:SolidPeso molecular:442.48BMS-1166-N-piperidine-CO-N-piperazine dihydrochloride
CAS:BMS-1166-N-piperidine-CO-N-piperazine dihydrochloride is a resorcinol di-Ph ether scaffold-based programmed cell death-1 (PD-1)/programmed cell death ligand 1 (Fórmula:C41H45Cl3N4O5Pureza:98%Cor e Forma:SoildPeso molecular:780.18TASIN-1 Hydrochloride
CAS:TASIN-1 Hydrochloride (TASIN-1 HCl) is a selective inhibitor of truncated APC that acts by selectively killing colorectal cancer cells that express truncatedFórmula:C18H29ClN2O3SPureza:99.84%Cor e Forma:SolidPeso molecular:388.95Ref: TM-T24855
1mg78,00€5mg143,00€10mg197,00€25mg335,00€50mg477,00€100mg662,00€200mg892,00€1mL*10mM (DMSO)150,00€Abemaciclib methanesulfonate
CAS:Abemaciclib methanesulfonate (LY2835219) is a specific and effective inhibitor of CDK4(IC50=2 nM) and CDK6(IC50=10 nM).Fórmula:C27H32F2N8·CH4O3SPureza:98.69% - 99.44%Cor e Forma:SolidPeso molecular:602.7CDK12/13-IN-2
CDK12/13-IN-2 (Compound 24) is a covalent inhibitor of CDK12 and CDK13, exhibiting IC50 values of 15.5 nM and 12.2 nM, respectively. It effectively inhibits the proliferation of breast cancer cells and can be utilized in the research of triple-negative breast cancer.Fórmula:C24H22FN7O2Cor e Forma:SolidPeso molecular:459.48WRN inhibitor 12
CAS:WRN inhibitor 12 (compound 5) serves as an inhibitor for the WRN helicase.Fórmula:C33H33ClF3N9O5Cor e Forma:SolidPeso molecular:728.12Cilengitide TFA
CAS:Cilengitide, αvβ3/αvβ5 inhibitor, IC50: 4.1/79 nM in vitro. 10x selectivity vs. gpIIbIIIa. Phase 2.Fórmula:C29H41F3N8O9Cor e Forma:SolidPeso molecular:702.68WAY-322243
CAS:WAY-322243 has antibacterial and anti-inflammatory activity and has an inhibitory effect on CLK-1, which can be used to study Alzheimer's disease.Fórmula:C18H18N2O2SPureza:99.47%Cor e Forma:SoildPeso molecular:326.41TP-353
CAS:TP-353 (EOS-61973) is a CDK7 inhibitor.Fórmula:C35H30FNO3Pureza:99.12%Cor e Forma:SolidPeso molecular:531.62Ref: TM-T22440
1mg59,00€2mg80,00€5mg108,00€10mg187,00€25mg341,00€50mg472,00€100mg652,00€200mg899,00€1mL*10mM (DMSO)158,00€CDK12/13 ligand 1
CAS:ALK-IN-29 (compound 4c) exhibits notable inhibitory activity against tyrosine kinases such as ALK, CDK2/CyclinE1, and FAK, with the strongest inhibition observed against ALK kinase, showing a 40.63% inhibition rate at a concentration of 10 μM. ALK-IN-29 is useful for cancer research.Fórmula:C26H26BrN5OCor e Forma:SolidPeso molecular:504.42D-I03
CAS:D-I03 is a selective RAD52 inhibitor with a Kd of 25.8 µM.Fórmula:C23H36N6SPureza:99.04%Cor e Forma:SolidPeso molecular:428.64Ref: TM-T10936
1mg37,00€2mg52,00€5mg77,00€10mg126,00€25mg283,00€50mg390,00€100mg567,00€1mL*10mM (DMSO)85,00€NY2267
CAS:NY2267 (Acetic acid, 2-[[6-[2-(cyclohexylamino)-1-[[(4-methoxyphenyl)methyl](2-pyridinylcarbonyl)amino]-2-oxoethyl]-2-naphthalenyl]oxy]-, 1,1-dimethylethylFórmula:C38H43N3O6Pureza:99.16% - 99.27%Cor e Forma:SolidPeso molecular:637.76Ref: TM-T9093
1mg87,00€5mg187,00€10mg298,00€25mg525,00€50mg747,00€100mg1.017,00€1mL*10mM (DMSO)264,00€WEE1-IN-11
CAS:WEE1-IN-11 (Compound 13) serves as a potent CDK2 inhibitor with an IC50 of 2.0 nM. It exhibits inhibitory effects on several cell lines, including NCI-H446, A427, OVCAR3, C33A, and WiDr, with respective IC50 values of 93.9, 34.5, 86.7, 23.1, and 85 nM.Fórmula:C26H29FN8OS2Cor e Forma:SolidPeso molecular:552.69Blinatumomab
CAS:Blinatumomab (AMG-10,MT-103) is a CD19/CD3 bispecific B-cell and T-cell binding antibody that in acute lymphoblastic leukemia and non-Hodgkin's lymphoma.Cor e Forma:LiquidAPE1-IN-1
CAS:APE1-IN-1 is a purine/pyrimidine-free endonuclease 1 inhibitor with potential antitumor activity that enhances the toxicity of alkylating agents on cancer cellsFórmula:C19H21N3OS2Pureza:98.50%Cor e Forma:SolidPeso molecular:371.52Plogosertib
CAS:Plogosertib (CYC140) is a PLK1 inhibitor with an IC50 value of 3 nM.Plogosertib is antiproliferative and can be used to study solid and hematologic tumors.Fórmula:C34H48N8O3Pureza:99.15% - 99.85%Cor e Forma:SolidPeso molecular:616.797P18IN003
CAS:P18IN003 is a selective and effective p18(INK4C) inhibitor that inhibits the activity of p18 protein and can be used to study in vitro expansion ofFórmula:C17H16N2O3Pureza:98.77%Cor e Forma:SolidPeso molecular:296.32AM5992
CAS:AM5992 (example 195) is a potent CDK4 and CDK6 inhibitor (CDK4, IC50= 0.013 μM). AM5992 can be used for the research of CDK4-mediated disorders.Fórmula:C27H33FN8OPureza:98%Cor e Forma:SoildPeso molecular:504.6Synstatin (92-119)
CAS:Synstatin (92-119) serves as an anti-tumor agent by suppressing angiogenesis and cancer cell invasion, chiefly through the down-regulation of integrin αvβ3 andFórmula:C133H207N35O46Pureza:98%Cor e Forma:SolidPeso molecular:3032.27GLPG0187
CAS:GLPG0187, a broad spectrum integrin receptor antagonist, inhibits αvβ1-integrin (IC50: 1.3 nM).Fórmula:C29H37N7O5SPureza:100% - 99.70%Cor e Forma:SolidPeso molecular:595.71P18IN011
CAS:P18IN011 (P18IN011 - CAS 77408-67-4 - Calbiochem) is a novel inhibitor of p18(INK4C).Fórmula:C15H12N2O5SPureza:97.63%Cor e Forma:SolidPeso molecular:332.33Ref: TM-T8576
1mg88,00€5mg170,00€10mg259,00€25mg425,00€50mg598,00€100mg810,00€200mg1.074,00€1mL*10mM (DMSO)178,00€Ethynylcytidine
CAS:Ethynylcytidine is a nucleoside antimetabolite.Fórmula:C11H13N3O5Pureza:98%Cor e Forma:SolidPeso molecular:267.24TMX-3013
CAS:TMX-3013 is a CDK inhibitor that targets multiple cyclin-dependent kinases, specifically suppressing the activity of CDK1, CDK2, CDK4, CDK5, and CDK6 with IC50 values of 0.9 nM, <0.5 nM, 24.5 nM, 0.5 nM, and 15.6 nM respectively. Additionally, TMX-3013 is utilized in the synthesis of PROTACs, which use polyethylene glycol (PEG) as a linker and Thalidomide as the CRBN-recruiting arm.Fórmula:C17H14BrFN6O3SCor e Forma:SolidPeso molecular:481.3UMK57
CAS:UMK57 is a CENP-Ei and MCAK enhancer, selectively promoting k-MT attachment error correction to inhibit chromosome missegregation of small molecule compounds,Fórmula:C17H17N3SPureza:99.81%Cor e Forma:SolidPeso molecular:295.4PD-1/PD-L1-IN-32
PD-1/PD-L1-IN-32 (compound A56) is a potent inhibitor of PD-1/PD-L1, displaying pronounced anticancer activity with an IC50 value of 2.4 nM.Pureza:98%Cor e Forma:Odour SolidTMPyP4 tosylate
CAS:TMPyP4 tosylate (TMP 1363) is a quadruplex-specific ligand and is a telomerase inhibitor with antitumor effects in osteosarcoma cell lines.Fórmula:C72H66N8O12S4Pureza:99.11% - 99.85%Cor e Forma:SolidPeso molecular:1363.6GSK4418959
CAS:GSK4418959 (IDE275) is an oral, non-covalent, reversible, and selective WRN helicase inhibitor.inhibits ATPase and DNA unwinding functions. MSI-H.Fórmula:C31H30F4N4O5SCor e Forma:SoildPeso molecular:646.65AVG-233
CAS:AVG-233 is an RNA-dependent RNA polymerase (RdRp) inhibitor with antiviral activity for the study of respiratory syncytial virus infections.Fórmula:C26H22ClN5O3Pureza:99%Cor e Forma:SolidPeso molecular:487.94GW8510
CAS:GW8510 is a CDK2 and RRM2 inhibitor that affects DNA synthesis and antiproliferation in tumor cells. In mammalian aging models, GW851 prolongs lifespan.Fórmula:C21H15N5O3S2Pureza:99.32%Cor e Forma:SolidPeso molecular:449.51Ref: TM-T24125
1mg52,00€5mg97,00€10mg169,00€25mg329,00€50mg537,00€100mg868,00€200mg1.169,00€1mL*10mM (DMSO)111,00€IMMH 010 maleate
CAS:IMMH 010 maleate (YPD-30 maleate) is a programmed cell death ligand 1 inhibitor used in the study of neurological disorders and advanced malignant solid tumors.Fórmula:C36H36BrClN2O9Cor e Forma:SoildPeso molecular:756.04NCGC00029283
CAS:NCGC00029283 is a potent inhibitor of Werner syndrome helicase-nuclease (WRN), displaying inhibitory activity against WRN helicase with an IC 50 value of 2.3 μMFórmula:C18H12FN3O3Pureza:99.6%Cor e Forma:SolidPeso molecular:337.3Ref: TM-T40823
1mg111,00€2mg163,00€5mg264,00€10mg432,00€25mg747,00€50mg1.103,00€100mg1.539,00€1mL*10mM (DMSO)283,00€Docosanoic acid
CAS:Docosanoic acid (Behenic Acid) is a long-chain saturated fatty acid. It has been found in peanut and M. oleifera seed oils.Fórmula:C22H44O2Pureza:100%Cor e Forma:Waxy Solid Liquid Othersolid PelletslargecrystalsPeso molecular:340.58N6-Methyladenine
CAS:N6-Methyladenine (6-(Methylamino)Purine) is a modified purine commonly found in genomes of prokaryotes, protists, and plants.Fórmula:C6H7N5Pureza:98.35%Cor e Forma:SolidPeso molecular:149.15Vaccarin
CAS:Vaccarin, a key flavonoid glycoside in Vaccariae semen, undergoes methylation, hydroxylation, glycosylation, and deglycosylation.Fórmula:C32H38O19Pureza:99.16% - 99.97%Cor e Forma:SolidPeso molecular:726.63Poloxin-2
CAS:Poloxin-2 is a potent and selective Plk1 PBD inhibitor with anti-tumour activity that reduces the protein level of Plk1 in HeLa cells.Fórmula:C16H15NO3Pureza:99.59%Cor e Forma:SolidPeso molecular:269.3Ref: TM-T25969
1mg333,00€5mg922,00€10mg1.140,00€25mg1.510,00€50mg1.882,00€100mg2.375,00€500mg4.664,00€2′-C-Methyl-6-O-methylinosine
CAS:6-MeO-9-(2-C-methyl-β-D-ribofuranosyl)purine is a hypoxanthine analog used in tumor disease research.Fórmula:C12H16N4O5Pureza:99.09%Cor e Forma:SolidPeso molecular:296.28Abrilumab
CAS:Abrilumab (MEDI-7183) is a fully human monoclonal antibody against α4β7 that inhibits the α4β7 integrin.Cor e Forma:LiquidXPW1
CAS:XPW1 is a CDK9 inhibitor with antitumor activity, inhibits DNA repair procedures, and can be used for the research of clear cell renal cell carcinoma.Fórmula:C36H39ClFN7O2Pureza:98.08%Cor e Forma:SoildPeso molecular:656.19Peldesine
CAS:Peldesine (BCX 34), an oral purine nucleoside phosphorylase blocker, halts T-cell growth; used in CTCL, psoriasis, HIV research. IC50: 800 nM.Fórmula:C12H11N5OPureza:99.27% - 99.95%Cor e Forma:SolidPeso molecular:241.25Ref: TM-T12399
1mg114,00€5mg274,00€10mg439,00€25mg727,00€50mg1.017,00€100mg1.378,00€500mg2.737,00€1mL*10mM (DMSO)303,00€Kinesore
CAS:Kinesore is a cell-permeable modulator that binds to the microtubule motor protein kinesin-1, thereby inhibiting the interaction between KLC2 and SKIP.Fórmula:C20H16Br2N4O4Pureza:97.24%Cor e Forma:SolidPeso molecular:536.17Ref: TM-T15663
2mg43,00€5mg66,00€10mg94,00€25mg159,00€50mg230,00€100mg346,00€200mg520,00€1mL*10mM (DMSO)74,00€c-Myc inhibitor 12
Compound 67h, also known as c-Myc inhibitor 12, is a potent inhibitor of c-Myc, exhibiting a pEC50 value of 6.4 [1].Fórmula:C22H24N6OPureza:98%Cor e Forma:SolidPeso molecular:388.478-Azaguanine
CAS:8-Azaguanine (SK 1150) is a purine analogue with potential antineoplastic activity.Fórmula:C4H4N6OPureza:100% - 99.89%Cor e Forma:White To Off-White Crystalline PowderPeso molecular:152.11Clofarabine-5'-diphosphate
CAS:Clofarabine-5'-diphosphate (Clofarabine-DP) is a metabolite resulting from the phosphorylation of Clofarabine by deoxycytidine kinase (dCK). It can undergo further phosphorylation to become Clofarabine-5'-triphosphate, exhibiting cytotoxicity in cancer cells by inhibiting DNA synthesis and repair.Fórmula:C10H13ClFN5O9P2Cor e Forma:SolidPeso molecular:463.64MC180295
CAS:MC180295 ((rel)-MC180295) is a novel potent, highly selective CDK9 inhibitor (IC50: 5 nM), displays >22-fold selectivity over other CDKs.Fórmula:C17H18N4O3SPureza:99.84%Cor e Forma:SolidPeso molecular:358.41Ref: TM-T5533
1mg56,00€5mg131,00€10mg187,00€25mg319,00€50mg449,00€100mg638,00€200mg842,00€1mL*10mM (DMSO)143,00€2'-Deoxycytidine hydrochloride
CAS:2'-Deoxycytidine hydrochloride is an important deoxyribonucleoside analog and protects mice from the lethal toxicity of cytosine arabinoside(araC).Fórmula:C9H14ClN3O4Pureza:98.96%Cor e Forma:White To Off-White Crystalline PowderPeso molecular:263.68
